Cat. #154791
Anti-CD11a (Integrin Subunit Alpha L ) [SPVL15]
Cat. #: 154791
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: CD11a
Class: Monoclonal
Application: FACS ; IP ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: Netherlands Cancer Institute
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-CD11a (Integrin Subunit Alpha L ) [SPVL15]
- Alternate name: ITGAL; LFA-1A
- Research fields: Cell biology;Cell signaling and signal transduction
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 126 kDa
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: FACS ; IP ; WB
- Description: ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signalling.
- Immunogen: Immunization of BALB/c mice with cells of the T4+T8- cytotoxic T lymphocyte clone HG-38
- Isotype: IgG2a
- Myeloma used: Sp2/0-Ag14
Target Details
- Target: CD11a
- Molecular weight: 126 kDa
- Target background: ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signalling.
Applications
- Application: FACS ; IP ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Lub et al. 1997. Mol Biol Cell. 8(4):719-28. PMID: 9247650.
