Anti-CD11a (Integrin aL) [38]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-CD11a (Integrin aL) [38]
• Alternate name: Integrin Subunit Alpha L; Leukocyte Function-Associated Molecule 1 Alpha Chain; CD11 Antigen-Like Family Member A; Antigen CD11A (P18); LFA-1A; CD11A; Antigen CD11A (P18); Lymphocyte Function-Associated Antigen 1; Lymphocyte Function-Associated Antigen 1; Alpha Polypeptide; Integrin Gene Promoter; Alpha Polypeptide; Integrin Alpha L; CD11a Antigen; LFA-1; LFA1A
• Research fields: Cell biology
• Clone: 38
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Molecular weight: 175 kDa
• Strain: Balb/c
• Reactivity: Human
• Host: Mouse
• Application: FACS ; IHC ; IF ; IP ; Fn
• Description: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin alpha L (CD11a) is expressed on all human leucocytes, with increased expression on memory T cells. This integrin has a major role in the migration of both normal and leukaemic leukocytes.
• Immunogen: Fibronectin purified monocytes.
• Isotype: IgG2a
• Myeloma used: Sp2/0-Ag14

Target Details

• Target: Integrin alpha L subunit (CD11a, LFA-1 alpha)
• Molecular weight: 175 kDa
• Target background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin alpha L (CD11a) is expressed on all human leucocytes, with increased expression on memory T cells. This integrin has a major role in the migration of both normal and leukaemic leukocytes.

Applications

• Application: FACS ; IHC ; IF ; IP ; Fn

Handling

• Format: Liquid
• Concentration: 1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Shipping at 4° C

References

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• Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells.
• Pathak et al. 2012. J Biol Chem. 287(17):13731-42. PMID: 22396536.
• Activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and ?2 integrins.
• Porter et al. 2009. FASEB J. 23(2):492-502. PMID: 18842965.
• Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium.
• McDowall et al. 2003. J Clin Invest. 111(1):51-60. PMID: 12511588.
• A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
• Stanley et al. 2000. Biochem J. 351(Pt 1):79-86. PMID: 10998349.
• The second domain of intercellular adhesion molecule-1 (ICAM-1) maintains the structural integrity of the leucocyte function-associated antigen-1 (LFA-1) ligand-binding site in the first domain.
• Dransfield et al. 1989. EMBO J. 8(12):3759-65. PMID: 2479549.
• Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits.
• Hogg et al. 1986. Eur J Immunol. 16(3):240-8. PMID: 3456894.
• The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules.