Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin alpha L (CD11a) is expressed on all human leucocytes, with increased expression on memory T cells. This integrin has a major role in the migration of both normal and leukaemic leukocytes.
| Inventor | Institute |
|---|---|
| Nancy Hogg | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151048 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology |
| Application: | FACS ; IHC ; IF ; IP ; Fn |
| Target: | Integrin alpha L subunit (CD11a, LFA-1 alpha) |
| Reactivity: | Human |
| Clone: | 38 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Dransfield et al. 1989. EMBO J. 8(12):3759-65. PMID: 2479549. |
| Alternate name: | Integrin Subunit Alpha L; Leukocyte Function-Associated Molecule 1 Alpha Chain; CD11 Antigen-Like Family Member A; Antigen CD11A (P18); LFA-1A; CD11A; Antigen CD11A (P18); Lymphocyte Function-Associated Antigen 1; Lymphocyte Function-Associated Antigen 1; Alpha Polypeptide; Integrin Gene Promoter; Alpha Polypeptide; Integrin Alpha L; CD11a Antigen; LFA-1; LFA1A |
|---|---|
| Product description: | Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin alpha L (CD11a) is expressed on all human leucocytes, with increased expression on memory T cells. This integrin has a major role in the migration of both normal and leukaemic leukocytes. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 175 kDa |
| Immunogen: | Fibronectin purified monocytes. |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin alpha L (CD11a) is expressed on all human leucocytes, with increased expression on memory T cells. This integrin has a major role in the migration of both normal and leukaemic leukocytes. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Iglesia et al. 2017. Stem Cell Res Ther. 8(1):76. PMID: 28412969. Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells. Pathak et al. 2012. J Biol Chem. 287(17):13731-42. PMID: 22396536. Activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and ?2 integrins. Porter et al. 2009. FASEB J. 23(2):492-502. PMID: 18842965. Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium. McDowall et al. 2003. J Clin Invest. 111(1):51-60. PMID: 12511588. A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins. Stanley et al. 2000. Biochem J. 351(Pt 1):79-86. PMID: 10998349. The second domain of intercellular adhesion molecule-1 (ICAM-1) maintains the structural integrity of the leucocyte function-associated antigen-1 (LFA-1) ligand-binding site in the first domain. Dransfield et al. 1989. EMBO J. 8(12):3759-65. PMID: 2479549. Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits. Hogg et al. 1986. Eur J Immunol. 16(3):240-8. PMID: 3456894. The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules. |
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