Cat. #151071
Anti-Alkaline phosphatase [AAP1]
Cat. #: 151071
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Alkaline phosphatase
Class: Monoclonal
Application: WB ; ELISA
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Walter Bodmer
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Alkaline phosphatase [AAP1]
- Research fields: Cancer;Cell biology
- Clone: AAP1
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: WB ; ELISA
- Description: Alkaline phosphatases are phosphodiesterases which remove phosphate groups from the 5' end of DNA, RNA and proteins at high pH. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. Detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer.
- Immunogen: D98/AH-2 (HeLa) cells, which produce human intestinal alkaline phosphatase ectopically
- Isotype: IgG2a
- Myeloma used: P3X63Ag8
Target Details
- Target: Alkaline phosphatase
- Target background: Alkaline phosphatases are phosphodiesterases which remove phosphate groups from the 5' end of DNA, RNA and proteins at high pH. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. Detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer.
Applications
- Application: WB ; ELISA
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Dry ice
References
- Brock et al. 1985. Lancet. 1(8439):1175-8. PMID: 2860384.
- Prospective prenatal diagnosis of cystic fibrosis.
- Arklie et al. 1981. Tissue Antigens. 17(3):303-12. PMID: 7314066.
- A monoclonal antibody to intestinal alkaline phosphatase made against D98/AH-2 (HeLa) cells.
