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#151071

Anti-Alkaline phosphatase [AAP1]

Cat. #151071

Anti-Alkaline phosphatase [AAP1]

Cat. #: 151071

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-4 weeks

Target: Alkaline phosphatase

Class: Monoclonal

Application: WB ; ELISA

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Walter Bodmer

Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-Alkaline phosphatase [AAP1]
  • Research fields: Cancer;Cell biology
  • Clone: AAP1
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Strain: Balb/c
  • Reactivity: Human
  • Host: Mouse
  • Application: WB ; ELISA
  • Description: Alkaline phosphatases are phosphodiesterases which remove phosphate groups from the 5' end of DNA, RNA and proteins at high pH. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. Detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer.
  • Immunogen: D98/AH-2 (HeLa) cells, which produce human intestinal alkaline phosphatase ectopically
  • Isotype: IgG2a
  • Myeloma used: P3X63Ag8

Target Details

  • Target: Alkaline phosphatase
  • Target background: Alkaline phosphatases are phosphodiesterases which remove phosphate groups from the 5' end of DNA, RNA and proteins at high pH. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. Detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer.

Applications

  • Application: WB ; ELISA

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Dry ice

References

  • Brock et al. 1985. Lancet. 1(8439):1175-8. PMID: 2860384.
  • Prospective prenatal diagnosis of cystic fibrosis.
  • Arklie et al. 1981. Tissue Antigens. 17(3):303-12. PMID: 7314066.
  • A monoclonal antibody to intestinal alkaline phosphatase made against D98/AH-2 (HeLa) cells.

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