Cat. #151523
Anti-a1 Connexin [1A]
Cat. #: 151523
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 1-2 weeks
Target: Connexin 43 (Cx43 or a1)
Class: Monoclonal
Application: IHC ; IF ; WB
Reactivity: Mouse
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: David Becker
Institute: University College London (UCL)
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-a1 Connexin [1A]
- Research fields: Cell signaling and signal transduction;Neurobiology
- Clone: 1A
- Tool sub type: Primary antibody
- Class: Monoclonal
- Purpose: Marker
- Conjugation: Unconjugated
- Reactivity: Mouse
- Host: Mouse
- Application: IHC ; IF ; WB
- Description: Connexins are a large family of proteins which form gap junctions. Gap junctions are cell membrane structures that facilitate direct cell-cell communication. Gap junction communication has been implicated in the patterning and development of vertebrate embryos. Individual connexins show complex spatial and temporal variation in expression patterns. This variation contributes to the control of intercellular signalling.
- Immunogen: The peptide, EIKKFKYGIEEH, was coupled at the C-terminal end to bovine thyroglobulin at a final molar ratio peptide:thyroglobulin of 4060:1.
- Isotype: IgG
- Myeloma used: P3X63Ag8.653
- Recommended controls: Heart & liver tissue from 6 week old mice; Heart tissue expresses predominantly Cx43
Target Details
- Target: Connexin 43 (Cx43 or a1)
- Tissue cell line specificity: Mouse
- Target background: Connexins are a large family of proteins which form gap junctions. Gap junctions are cell membrane structures that facilitate direct cell-cell communication. Gap junction communication has been implicated in the patterning and development of vertebrate embryos. Individual connexins show complex spatial and temporal variation in expression patterns. This variation contributes to the control of intercellular signalling.
Applications
- Application: IHC ; IF ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Gorbe et al. 2007. Exp Cell Res. 313(6):1135-48. PMID: 17331498.
- Myoblast proliferation and syncytial fusion both depend on connexin43 function in transfected skeletal muscle primary cultures.
- Pearson et al. 2005. J Neurosci. 25(46):10803-14. PMID: 16291954.
- Gap junctions modulate interkinetic nuclear movement in retinal progenitor cells.
- Saitongdee et al. 2004. J Histochem Cytochem. 52(5):603-15. PMID: 15100238.
- Levels of gap junction proteins in coronary arterioles and aorta of ha...
