Cat. #151622
Anti-a-MMP9 [4A3]
Cat. #: 151622
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 1-2 weeks
Target: Activated MMP9 (matrix metalloproteinase 9)
Class: Monoclonal
Application: ELISA ; IHC ; WB
Reactivity: Human ; Rat
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Ayham Alnabulsi
Institute: Vertebrate Antibodies Limited
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-a-MMP9 [4A3]
- Research fields: Biochemistry;Cancer;Cell biology;Cell signaling and signal transduction;Tissue-specific biology
- Clone: 4A3
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Human ; Rat
- Host: Mouse
- Application: ELISA ; IHC ; WB
- Description: Matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix (ECM) in normal physiological processes as well as in disease processes. Tissue inhibitors of metalloproteinases (TIMPs) are the main physiological regulators of the MMPs. The TIMPs are secreted proteins that complex with individual MMPs and regulate the activity of specific MMPs. Together, the MMPs and TIMPs form a complex biological system strictly controlling degradation of ECM. The MMPs and TIMPs have a significant role in facilitating tumour invasion and metastasis
- Immunogen: Ovalbumin-conjugated synthetic peptide; acetylated-FQTFEGDLK
- Isotype: IgG1 kappa
- Myeloma used: P3X63Ag8.653
- Recommended controls: IHC: Formaldehyde-fixed, wax-embedded oesophegal adenocarcinomaWestern Blot Activated recombinant MMP-9, 400ng per lane
Target Details
- Target: Activated MMP9 (matrix metalloproteinase 9)
- Tissue cell line specificity: IHC: Formaldehyde-fixed, wax-embedded oesophegal adenocarcinomaWestern Blot Activated recombinant MMP-9, 400ng per lane
- Target background: Matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix (ECM) in normal physiological processes as well as in disease processes. Tissue inhibitors of metalloproteinases (TIMPs) are the main physiological regulators of the MMPs. The TIMPs are secreted proteins that complex with individual MMPs and regulate the activity of specific MMPs. Together, the MMPs and TIMPs form a complex biological system strictly controlling degradation of ECM. The MMPs and TIMPs have a significant role in facilitating tumour invasion and metastasis
Applications
- Application: ELISA ; IHC ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Cirella et al. 2016. Thesis
- Goktolga et al. 2015. Exp Ther Med. 9(5):1813-1818. PMID: 26136898.
- Effect of the non-specific matrix metalloproteinase inhibitor Doxycycline on endometriotic implants in an experimental rat model.
- Duncan et al. 1998. Eur J Biochem. 258(1):37-43. PMID: 9851689.
- Human matrix metalloproteinase-9: activation by limited trypsin treatment and generation of monoclonal antibodies specific for the activated form.
