Anti-(1-5)-a-L-arabinan (linear) [LM13]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-(1-5)-a-L-arabinan (linear) [LM13]
• Alternate name: Linear epitope in (1-5)-?-L-arabinans
• Research fields: Biochemistry
• Class: Monoclonal
• Conjugation: Unconjugated
• Host: Rat
• Description: Carbohydrate microarrays provide a means of rapidly screening the interactions between glycans and other molecules. Applications for this technology include the screening of protein–glycan interactions, characterization of carbohydrate-active enzymes and the analysis of the specificities of monoclonal antibodies (mAbs) and carbohydrate-binding modules. mAbs are powerful tools for investigating the biological roles of glycans. Plant cell walls are fibre composites that contain some of the most complex glycans known. In addition to their biological roles, many cell wall components have important industrial applications including as functional food ingredients, pharmaceuticals, nutriceuticals, fibres and increasingly, bio-fuels. However, the complexity and heterogeneity of cell wall components presents a major barrier to detailed analysis and our understanding of many aspects of plant cell wall structure and function is far from complete. Furthermore, the repertoire of mAbs currently available for plant cell wall components covers only a small proportion of the glycan structures that have been identified and there is pressing need for a wider range of mAbs to facilitate the further characterization of cell walls.
• Immunogen: Pectic fraction
• Myeloma used: IR983F
• Recommended controls: IgM

Target Details

• Target: (1-5)-a-L-arabinan (linear)
• Target background: Carbohydrate microarrays provide a means of rapidly screening the interactions between glycans and other molecules. Applications for this technology include the screening of protein–glycan interactions, characterization of carbohydrate-active enzymes and the analysis of the specificities of monoclonal antibodies (mAbs) and carbohydrate-binding modules. mAbs are powerful tools for investigating the biological roles of glycans. Plant cell walls are fibre composites that contain some of the most complex glycans known. In addition to their biological roles, many cell wall components have important industrial applications including as functional food ingredients, pharmaceuticals, nutriceuticals, fibres and increasingly, bio-fuels. However, the complexity and heterogeneity of cell wall components presents a major barrier to detailed analysis and our understanding of many aspects of plant cell wall structure and function is far from complete. Furthermore, the repertoire of mAbs currently available for plant cell wall components covers only a small proportion of the glycan structures that have been identified and there is pressing need for a wider range of mAbs to facilitate the further characterization of cell walls.

Handling

• Format: Liquid
• Unit size: 100 ug
• Shipping conditions: Shipping at 4° C

References

• Verhertbruggen et al. 2009. Plant J. 59(3):413-25. PMID: 19392693.
• Moller et al. 2008. Glycoconj J. 25(1):37-48. PMID: 17629746.