Cat. #151880

AKR1C3 inhibitor CRT0093964 Small Molecule (Tool Compound)

Cat. #: 151880

Sub-type: Inhibitor

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Contributor

Inventor: Laurent Rigoreau

Institute: Cancer Research Technology

Tool Details

Handling

Target Details

Related Tools

References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

Tool name: AKR1C3 inhibitor CRT0093964 Small Molecule (Tool Compound)
Research fields: Cell signaling and signal transduction;Metabolism;Neurobiology
Molecular formula: C15H20CIN3O2
Tool sub type: Inhibitor
Primary target: Type 5 17-?-Hydroxysteroid Dehydrogenase (AKR1C3)
Description: CRT0093964 is a highly potent and selective inhibitor of the Type 5 17-?-Hydroxysteroid Dehydrogenase (AKR1C3).
Purpose: Inhibitor
Selectivity: Displays >100-fold selectivity against AKR1C1, AKR1C2 and AKR1C4. Does not display any COX (cyclooxygenase) inhibition at 10 ÂľM in whole blood assay.
Iupac: 4-(4-Chloro-phenyl)-piperazin-1-yl]-morpholin-4-yl-methanone
Molecular weight: 309.79
Additional notes: Referred to as A9 in Khanim et al., 2014.

Handling

Purity: 309.79 g/mol
Shipping conditions: Dry Ice

Target Details

Primary target: Type 5 17-?-Hydroxysteroid Dehydrogenase (AKR1C3)
Ic50: IC50 = 88 nM

Related Tools

Related tools: AKR1C3 inhibitor CRT0083914 Small Molecule (Tool Compound) ; AKR1C3 inhibitor CRT0036521 Small Molecule (Tool Compound)

References

Khanim et al. 2014. Br J Cancer. 110(6):1506-16. PMID: 24569460.