AKR1C3 inhibitor CRT0083914 Small Molecule (Tool Compound)

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Tool name: AKR1C3 inhibitor CRT0083914 Small Molecule (Tool Compound)
• Research fields: Cell signaling and signal transduction;Neurobiology
• Molecular formula: C16H22N2O3S
• Tool sub type: Inhibitor
• Primary target: AKR1C3
• Description: CRT0083914 is a novel non-carboxylate inhibitors of the aldo-ketoreductase enzyme AKR1C3, which is a target of interest in breast and prostate cancer and also some leukaemias.
• Purpose: Inhibitor
• Selectivity: Displays much weaker inhibitory activity against AKR1C1, AKR1C2 and AKR1C4 (IC50 >30 ÂľM).
• Iupac: 1-[4-(2-Methyl-piperidine-1-sulfonyl)-phenyl]-pyrrolidin-2-one
• Molecular weight: 322.43
• Additional notes: CRT0083914: a series of (piperidinosulfonamidophenyl)pyrrolidin-2-ones as potent (<100 nM) and isoform-selective non-carboxylate inhibitors of AKR1C3. Structure–activity relationships identified the sulfonamide was critical, and a crystal structure showed the 2-pyrrolidinone does not interact directly with residues in the oxyanion hole. Variations in the position, co-planarity or electronic nature of the pyrrolidinone ring severely diminished activity, as did altering the size or polarity o...

Handling

• Purity: 322.43 g/mol
• Shipping conditions: Dry Ice

Target Details

• Primary target: AKR1C3
• Ic50: IC50 = 94 nM

Related Tools

• Related tools: AKR1C3 inhibitor CRT0036521 Small Molecule (Tool Compound) ; AKR1C3 inhibitor CRT0093964 Small Molecule (Tool Compound)

References

• CRT0083914- Heinrich et al. 2013. Eur J Med. Chem. PMID: 23454516