Cat. #157649
NF712 peptide
Cat. #: 157649
Sub-type: Synthetic Peptide
Availability: Please enquire for quantities and pricing
Target: Other
Function: siRNA delivery
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Piret Arukuusk ; Ly Porosk ; Ülo Langel
Institute: University of Tartu
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: NF712 peptide
- Alternate name: NickFect712
- Research fields: Genetics
- Tool sub type: Synthetic Peptide
- Sequence: HHYHHGO(ILLKALKALAKAIL)
- Cellular tissue localisation: Cell-penetrating peptide to assist delivery of siRNA into cells via endocytosis
- Source: Solid-phase synthesis
- Target: Other
- Description: This peptide can be used to transport siRNA into cells. Use of cell-penetration peptides can increase the transport efficiency of extracellular synthetic nucleic acids, such as siRNAs, to help increase concentration of the siRNA at the desired cellular location. This peptide is based on NickFect55 (NF55) which is a peptide that can efficiently transport plasmid DNA into cells in vivo. To improve the efficiency of nucleic acid delivery, this peptide has been developed to improve the intracellular release mechanism resulting in higher local dosage of the cargo.
- Function: siRNA delivery
- Tag: arachidyl (20-carbon) fatty acid chain attached to the N-terminus of the peptide
- Expression system: Synthetic
- Additional notes: There is an arachidyl (20-carbon) fatty acid chain attached to the N-terminus of the peptide. The sequence in brackets is attached to the sidechain amino group rather than the a-amino group.
Handling
- Shipping conditions: Dry Ice
Target Details
- Target: Other
Application Details
- Application notes: There is an arachidyl (20-carbon) fatty acid chain attached to the N-terminus of the peptide. The sequence in brackets is attached to the sidechain amino group rather than the Îą-amino group.
References
- Porosk et al. 2019. Biomater Sci. 7(10):4363-4374. PMID: 31411219.
