#154132

CHEC-7 immunomodulatory Peptide

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Cat. #154132

CHEC-7 immunomodulatory Peptide

Cat. #: 154132

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This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Timothy Cunningham

Institute: Drexel University

Tool Details
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: CHEC-7 immunomodulatory Peptide
  • Alternate name: Human neuroprotective polypeptide Diffusible Survival Evasion Peptide (DSEP)
  • Research fields: Immunology;Neurobiology
  • Sequence: CHEASQC
  • Description: The CHEC-7 (peptide sequence CHEASQC) peptide is modified from immunomodulatory CHEC-9 peptide by eliminating two central alanines followed by cyclization to be a more potent uncompetitive sPLA2 inhibitor. The neuroprotective/anti-inflammatory cyclic heptapeptide, CHEC-7, stimulates HSP70's disaggregase activity and is used in the study of protein aggregate disease, including age-related failures of protein repair like Alzheimer’s Disease. The peptide also showed promising results in treating Autoimmune Myeloencephalitis tested in a rat model.

Handling

  • Shipping conditions: Dry Ice

References

  • Cunningham et al. 2018. Rejuvenation Res. 21(6):527-534. PMID: 29651925.
  • Heptamer Peptide Disassembles Native Amyloid in Human Plasma Through Heat Shock Protein 70.
  • Uncompetitive Phospholipase A2 Inhibition by CHEC Sequences Including Oral Treatment of Experimental Autoimmune Myeloencephalitis