CHEC-7 immunomodulatory Peptide

The CHEC-7 (peptide sequence CHEASQC) peptide is modified from immunomodulatory CHEC-9 peptide by eliminating two central alanines followed by cyclization to be a more potent uncompetitive sPLA2 inhibitor

Contributors

Inventor Institute
Timothy Cunningham Drexel University
Cat. #: 154132
Research Fields: Immunology;Neurobiology
Alternate name: Human neuroprotective polypeptide Diffusible Survival Evasion Peptide (DSEP)
Product description: The CHEC-7 (peptide sequence CHEASQC) peptide is modified from immunomodulatory CHEC-9 peptide by eliminating two central alanines followed by cyclization to be a more potent uncompetitive sPLA2 inhibitor. The neuroprotective/anti-inflammatory cyclic heptapeptide, CHEC-7, stimulates HSP70's disaggregase activity and is used in the study of protein aggregate disease, including age-related failures of protein repair like Alzheimer’s Disease. The peptide also showed promising results in treating Autoimmune Myeloencephalitis tested in a rat model.
References:

Cunningham et al. 2018. Rejuvenation Res. 21(6):527-534. PMID: 29651925.

Heptamer Peptide Disassembles Native Amyloid in Human Plasma Through Heat Shock Protein 70.

Uncompetitive Phospholipase A2 Inhibition by CHEC Sequences Including Oral Treatment of Experimental Autoimmune Myeloencephalitis

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