[…] widely used antibodies for targets with key functions in tumour signalling pathways including tumour suppressors ( p53, RB1), oncogenes (c-MYC), and tumour associated antigens (MUC1). Tumour suppressors Antibodies targeting p53, Retinoblastoma […]
Cells derived from a female mouse with cutaneous squamous cell carcinoma (SCC) lacking osteopontin (OPN) gene. Cells contain p53 and H-ras mutations
Delta Np73 is capable of regulating TAp73 and p53 function
TAp73 is a structural homologue of the pre-eminent tumour suppressor p53
Delta Np73 is capable of regulating TAp73 and p53 function
Heterozygous loss of Sufu, in conjunction with the loss of p53, leads to the development of medulloblastoma and rhabdomyosarcoma. Somatic Sufu mutations have been identified in multiple other malignancies, including […]
UbcH5B, encoded by the UBE2D2 gene, is a member of the E2 ubiquitin-conjugating enzyme family And is involved in the ubiquitination of p53.
SV40 is a simian oncogenic polyoma virus. The SV40 large T antigen is an early protein that interacts with the p53 and Rb tumour suppressor proteins.
[…] the original dysplasia. Growth is stimulated by hydrocortisone and inhibited by cholera toxin. Expression of p53 is increased and a 12 bp in-frame deletion of the p53 gene (codon 188-191) […]
![HCT 116 p300 KO [F2] Cell Line. Early log phase. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC), UK.](https://cancertools.org/wp-content/uploads/HCT-116-p300-KO-F2-Cell-Line.-Early-log-phase.png)
[…] HCT 116 p300 KO Cell Line is a tool for the in vitro study of p300 in colon carcinoma, and specifically of its role in p53-dependent apoptosis, cellular adhesion and migration.
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