Anti-TAp73 [TAp73-1.1] Product
TAp73 is a structural homologue of the pre-eminent tumour suppressor p53
TAp73 is a structural homologue of the pre-eminent tumour suppressor p53
iASPP1 inhibits the proaptotic functions of ASPP1 and p53.
Delta Np73 is capable of regulating TAp73 and p53 function
SV40 is a simian oncogenic polyoma virus. The SV40 large T antigen is an early protein that interacts with the p53 and Rb tumour suppressor proteins.
Heterozygous loss of Sufu, in conjunction with the loss of p53, leads to the development of medulloblastoma and rhabdomyosarcoma. Somatic Sufu mutations have been identified in multiple other malignancies, including […]
UbcH5B, encoded by the UBE2D2 gene, is a member of the E2 ubiquitin-conjugating enzyme family And is involved in the ubiquitination of p53.
[…] (Plx) is a mitotic regulator conserved from yeasts to humans. Many key cell cycle regulators such as p53, cdc25, cyclin B and the Anaphase Promoting Complex are directly targeted by Plx.
[…] line derived from a squamous cell carcinoma of the tongue of a Caucasian male. Keratin and involucrin markers present. Known mutations: p53, p16 and p14ARF. Cells are tumourigenic in athymic mice.
[…] cell carcinoma of the tongue of a Caucasian female. Keratin and involucrin markers present. Known mutations: p53 and p16. Cells are tumourigenic in athymic mice. Epidermal Growth Factor Receptor (EGFR) present.
[…] derived from a recurrent squamous cell carcinoma of the tongue of a Caucasian male. Keratin and involucrin markers present. Known mutations: p53, p16 and p14ARF. Cells are tumourigenic in athymic mice.
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