Mapt-9A18 phosphodefective Tau Mouse

Cat. #152794

Mapt-9A18 phosphodefective Tau Mouse

Cat. #: 152794

Sub-type: Mouse

Availability: 6-8 weeks

Disease: Dementia

Model: Knock-In

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Inventor: Michael Coleman

Institute: Babraham Institute

Tool Details
Target Details
Related Tools

Tool Details


  • Tool name: Mapt-9A18 phosphodefective Tau Mouse
  • Alternate name: MAPT, Neurofibrillary tangle protein, paired helical filament-tau, PHF-tau
  • Research fields: Cell biology;Genetics;Neurobiology
  • Tool sub type: Mouse
  • Disease: Dementia
  • Model: Knock-In
  • Conditional: No
  • Description: Hyperphosphorylation and fibrillar aggregation of the microtubule-associated protein tau are key features of Alzheimer's disease and other tauopathies. Tauopathies are characterized by aggregation of microtubule-associated protein tau into neurofibrillary tangles (NFTs). The Mapt-9A18 phosphodefective tau knockin mouse expresses phosphodefective tau with 18 alanine substitutions at serine and/or threonine residues in the proline-rich and first microtubule-binding domains to model hyperphosphorylation. This is a matched counterpart mouse model for the Mapt9E18 phosphomimetic tau knockin mouse which has 18 glutamate substitutions as a model of an inherited taupathy; frontotemporal dementia with parkinsonism linked to tau mutations on chromosome 17 (FTDP-17T).
  • Strain: C57BL/6

Target Details

  • Target: Microtubule-associated protein Tau

Related Tools

  • Related tools: Mapt-9E18 phosphomimetic Tau Mouse


  • Gilley J et al. Neurobiol Aging. 2016 Mar
  • 39:1-18
  • PMID: 26923397