Cat. #151518
Lupus Mouse
Cat. #: 151518
Sub-type: Mouse
Availability: 6-8 weeks
Disease: Systemic Lupus Erythematosus (SLE); Autoimmune disease
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Fiona Watt
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: Lupus Mouse
- Tool sub type: Mouse
- Disease: Systemic Lupus Erythematosus (SLE); Autoimmune disease
- Conditional: Yes
- Description: Disease model for systemic lupus erythematosus; in vivo study of IFNg expression in skin
- Genetic background: An involucrin-interferon transgene expression construct was injected into fertilised oocytes from F1 hybrid CBA/C57BL/10 mice. Transgene-positive mice were mated to C57BL/10 mice to generate founder lines.
- Phenotype: The Inv-IFNg mouse presents a phenotype analogous to systemic lupus erythematosus, and is an ideal tool for study of the disease in vivo.Inv-IFNg mice demonstrate key features of the lupus pathology:Skin abnormalities;- retarded hair growth, hypopigmentation of hair- extreme age-related erythema (reddening of skin)- flaky and pustular skin lesions, particularly around joints and appendagesDevelopmental abnormalities;- growth retardation- hunched appearance, odd gait- enlarged spleens, shrunken thymusImmune abnormalities;- contact hypersensitivity- autoantibody production, nephritis
- Zygosity: Heterozygous
- Production details: An involucrin-interferon transgene expression construct was injected into fertilised oocytes from F1 hybrid CBA/C57BL/10 mice. Transgene-positive mice were mated to C57BL/10 mice to generate founder lines.
- Additional notes: The Inv-IFNg mouse presents a phenotype analogous to systemic lupus erythematosus, and is an ideal tool for study of the disease in vivo.Inv-IFNg mice demonstrate key features of the lupus pathology:Skin abnormalities;- retarded hair growth, hypopigmentation of hair- extreme age-related erythema (reddening of skin)- flaky and pustular skin lesions, particularly around joints and appendagesDevelopmental abnormalities;- growth retardation- hunched appearance, odd gait- enlarged spleens, shrunken thymusImmune abnormalities;- contact hypersensitivity- autoantibody production, nephritis
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Target Details
- Target: Interferon-g (IFNg)
