Lupus Mouse

Disease model for systemic lupus erythematosus; in vivo study of IFNg expression in skin

Contributors

Inventor Institute
Fiona Watt Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151518
Research Fields: Genetics;Immunology
Target: Interferon-g (IFNg)
disease: Systemic Lupus Erythematosus (SLE)
Zygosity: Heterozygous
Phenotype: The Inv-IFNg mouse presents a phenotype analogous to systemic lupus erythematosus, and is an ideal tool for study of the disease in vivo.Inv-IFNg mice demonstrate key features of the lupus pathology:Skin abnormalities;- retarded hair growth, hypopigmentation of hair- extreme age-related erythema (reddening of skin)- flaky and pustular skin lesions, particularly around joints and appendagesDevelopmental abnormalities;- growth retardation- hunched appearance, odd gait- enlarged spleens, shrunken thymusImmune abnormalities;- contact hypersensitivity- autoantibody production, nephritis
Product description: Disease model for systemic lupus erythematosus; in vivo study of IFNg expression in skin
Conditional: Yes
Genetic background: An involucrin-interferon transgene expression construct was injected into fertilised oocytes from F1 hybrid CBA/C57BL/10 mice. Transgene-positive mice were mated to C57BL/10 mice to generate founder lines.
Production details: An involucrin-interferon transgene expression construct was injected into fertilised oocytes from F1 hybrid CBA/C57BL/10 mice. Transgene-positive mice were mated to C57BL/10 mice to generate founder lines.
Additional notes: The Inv-IFNg mouse presents a phenotype analogous to systemic lupus erythematosus, and is an ideal tool for study of the disease in vivo.Inv-IFNg mice demonstrate key features of the lupus pathology:Skin abnormalities;- retarded hair growth, hypopigmentation of hair- extreme age-related erythema (reddening of skin)- flaky and pustular skin lesions, particularly around joints and appendagesDevelopmental abnormalities;- growth retardation- hunched appearance, odd gait- enlarged spleens, shrunken thymusImmune abnormalities;- contact hypersensitivity- autoantibody production, nephritis
Shipping conditions: Embryo/Spermatoza- Dry Ice

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