#151518

Lupus Mouse

Cat. #151518

Lupus Mouse

Cat. #: 151518

Sub-type: Mouse

Availability: 6-8 weeks

Disease: Systemic Lupus Erythematosus (SLE)

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Fiona Watt

Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details
Handling
Target Details

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: Lupus Mouse
  • Research fields: Genetics;Immunology
  • Tool sub type: Mouse
  • Disease: Systemic Lupus Erythematosus (SLE)
  • Conditional: Yes
  • Description: Disease model for systemic lupus erythematosus; in vivo study of IFNg expression in skin
  • Genetic background: An involucrin-interferon transgene expression construct was injected into fertilised oocytes from F1 hybrid CBA/C57BL/10 mice. Transgene-positive mice were mated to C57BL/10 mice to generate founder lines.
  • Phenotype: The Inv-IFNg mouse presents a phenotype analogous to systemic lupus erythematosus, and is an ideal tool for study of the disease in vivo.Inv-IFNg mice demonstrate key features of the lupus pathology:Skin abnormalities;- retarded hair growth, hypopigmentation of hair- extreme age-related erythema (reddening of skin)- flaky and pustular skin lesions, particularly around joints and appendagesDevelopmental abnormalities;- growth retardation- hunched appearance, odd gait- enlarged spleens, shrunken thymusImmune abnormalities;- contact hypersensitivity- autoantibody production, nephritis
  • Zygosity: Heterozygous
  • Production details: An involucrin-interferon transgene expression construct was injected into fertilised oocytes from F1 hybrid CBA/C57BL/10 mice. Transgene-positive mice were mated to C57BL/10 mice to generate founder lines.
  • Additional notes: The Inv-IFNg mouse presents a phenotype analogous to systemic lupus erythematosus, and is an ideal tool for study of the disease in vivo.Inv-IFNg mice demonstrate key features of the lupus pathology:Skin abnormalities;- retarded hair growth, hypopigmentation of hair- extreme age-related erythema (reddening of skin)- flaky and pustular skin lesions, particularly around joints and appendagesDevelopmental abnormalities;- growth retardation- hunched appearance, odd gait- enlarged spleens, shrunken thymusImmune abnormalities;- contact hypersensitivity- autoantibody production, nephritis

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Target Details

  • Target: Interferon-g (IFNg)