K14dNLef1 Mouse

In vivo study of Lef1 activity in skin; model for hair growth & follicle formation; disease model for skin tumour formation (sebaceous adenoma, sebeoma, squamous papilloma)

Contributors

Inventor Institute
Fiona Watt Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151564
Cancer types: Gynaecologic cancer;Skin cancer
Research Fields: Cancer;Cell signaling and signal transduction;Developmental biology;Genetics;Stem cell biology
Target: Lef1 N-terminal mutant (constituitive transcirptional activity)
disease: Cancer
Phenotype: Tumourigenesis (skin); skin abnormalities (hair follicle, sebaceous gland)
Product description: In vivo study of Lef1 activity in skin; model for hair growth & follicle formation; disease model for skin tumour formation (sebaceous adenoma, sebeoma, squamous papilloma)
Conditional: Yes
Conditional description: Conditional expression of deltaN-Lef1 under Keratin 14 promoter giving tissue-specific epidermal expression.
Genetic background: A deltaNLef1 transgene vector, containing an N-terminally deleted mouse Lef1 cDNA under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.
Production details: A deltaNLef1 transgene vector, containing an N-terminally deleted mouse Lef1 cDNA under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Niemann et al. 2002. Development. 129(1):95-109. PMID: 11782404.

Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours.

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