#157781

iCKO-Myrf mouse

Cat. #157781

iCKO-Myrf mouse

Cat. #: 157781

Sub-type: Mouse

Availability: 6-8 weeks

Disease: Tamoxifen inducible knockout of Myrf in mature oligodendrocytes

Model: Conditional KO

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Ben Emery

Institute: Oregon Health & Science University

Tool Details
Handling
Target Details
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: iCKO-Myrf mouse
  • Research fields: Neurobiology
  • Tool sub type: Mouse
  • Disease: Tamoxifen inducible knockout of Myrf in mature oligodendrocytes
  • Model: Conditional KO
  • Conditional: Yes
  • Conditional description: inducible conditional myelin regulatory factor knockout mouse
  • Description: inducible knockout of Myrf in oligodendrocytes, critical for myelin formation in CNS.
  • Genetic background: MyrfFl/Fl male + PLP-Cre/MyrfFl/Fl female or PLP-Cre/MyrfFl/Fl male + MyrfFl/Fl female. Provides iCKO-Myrf pups at 50%
  • Phenotype: iCKO-Myrf
  • Strain: C57BL/6
  • Breeding information: MyrfFl/Fl male + PLP-Cre/MyrfFl/Fl female or PLP-Cre/MyrfFl/Fl male + MyrfFl/Fl female. Provides iCKO-Myrf pups at 50%

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Target Details

  • Target: Myrf (myelin regulatory factor)

References

  • Koenning et al. 2012. J Neurosci. 32(36):12528-42. PMID: 22956843.
  • Emery et al. 2009. Cell. 138(1):172-85. PMID: 19596243.
  • Doerflinger et al. 2003. Genesis. 35(1):63-72. PMID: 12481300.