Cat. #157948
CXCR3-GFP knock-in mouse
Cat. #: 157948
Sub-type: Mouse
Availability: 6-8 weeks
Disease: Allergic responses
Model: Knock-In
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Abhay Satoskar
Institute: Ohio State University
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: CXCR3-GFP knock-in mouse
- Research fields: Cancer;Immunology
- Tool sub type: Mouse
- Disease: Allergic responses
- Model: Knock-In
- Description: Chemokines are typically small, secreted molecules that participate in leukocyte trafficking, recruitment, and activation. They also play roles in normal and pathological processes including allergic responses, infectious and autoimmune disease, angiogenesis, inflammation, and tumor growth and metastasis. CXC chemokine receptor 3 (CXCR3) is expressed by natural killer cells, neutrophils, T cells and plasmacytoid dendritic cells. CXCR3 ligands are produced in extremely high levels during inflammation and infection, but they may also be possible targets for development of therapeutics for autoimmune and cancer diseases. There is a significant need for animal models to track and investigate CXCR3 expressing cells for diagnostic and therapeutic tool development.
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Target Details
- Target: CXCR3
References
- Cohen et al. 2013. PLoS Pathog. 9(10):e1003706. PMID: 24130498.
- Oghumu et al. 2013. J Immunol. 190(5):2229-40. PMID: 23338236.
