Edith HEARD; Rafael GALUPA; Fatima El Marjou; Colin Jouhanneau
Institut Curie
SKU:
162170
Product description:
This line was generated in the context of studying the relationship between chromosome organisation and gene expression at the X-inactivation centre, the regulatory locus that triggers X-chromosome inactivation. It could also be used to investigate the functions of the poorly characterised locus Chic1, for which one exon is deleted.
Official nomenclature:
B6D2Fn-chic1em1Heard/Curie
CRISPR:
Yes
Cat. #:
162170
Research Fields:
Genetics
Zygosity:
Homozygous
Strain:
B6D2F1
Primary citation:
Rafael Galupa et. al. 2022. Development. May 1;149(9):dev200568. PMID: 35502750.
Inversion of Linx cluster of CTCF sites leads to Xist upregulation in cis. (A) The Linx locus, CTCF binding, and orientation of CTCF motifs associated with CTCF ChIP-seq peaks. The red and blue arrowheads indicate the orientation of the CTCF motif (orientated left or right, respectively). The targeted inversions Linx-25 kb-INV and Linx-51 kb-INV are indicated.
(F) (Up) RNA allelic ratios for Xist and the X-linked gene Atp7a. Each black dot corresponds to a single female embryo. Box-and-whisker plots indicate median, interquartile range and min/max values, with blue and red plots indicating paternally or maternally inherited alleles, respectively. (Down) Crosses used for analysis of RNA allelic ratios in female hybrid embryos inheriting the Mus musculus domesticus allele paternally (blue).
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