Edith HEARD; Rafael GALUPA; Fatima EL MARJOU; Colin JOUHANNEAU
Institut Curie
SKU:
162172
Product description:
This line was generated in the context of studying the relationship between chromosome organisation and gene expression at the X-inactivation centre, the regulatory locus that triggers X-chromosome inactivation. It could also be used to investigate the functions of the genes that are lost within the ~245kb deletion, including the poorly characterised genes Nap1L2, Cdx4, Chic1 and Tsx, among others.
Official nomenclature:
B6D2Fn-Tsix-TADem2Heard/Curie
CRISPR:
Yes
Cat. #:
162172
Research Fields:
Genetics
Zygosity:
Homozygous
Strain:
B6D2F1
Primary citation:
Rafael Galupa et.al. 2020. Mol Cell. Jan 16;77(2):352-367.e8. PMID: 31759823.
The Tsix-TAD regulates not only Tsix but also Xist, in part via LinxP which also influences choice making during random XCI by regulating Xist expression in cis. Linx transcription affects local topology but is not necessary for Xist regulation. LinxP is conserved in sequence and synteny across placental mammals.
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