Monocyte Chemoattractant Protein-1-Induced Protein-1 (MCPIP1) knockout mouse

Primary biliary cholangitis (PBC) is an autoimmune disease characterized by progressive destruction of the intrahepatic bile ducts.

Contributors

Inventor Institute
Jerzy Kotlinowski ; Natalia Pydyn ; Edyta Kus ; Stefan Chlopicki ; Jolanta Jura Jagiellonian University
SKU: 160590
Product description: Primary biliary cholangitis (PBC) is an autoimmune disease characterized by progressive destruction of the intrahepatic bile ducts.
Alternate name: Regnase1, Zc3h12a
Additional notes: Adapted from Kotlinowski J. et al. bioRxiv; 2020. DOI: 10.1101/2020.09.05.250522: This mouse model was developed to verify whether Mcpip1 expression protects against development of PBC. Deletion of hepatic Mcpip1 in Mcpip1AlbKO mice leads to development of PBC that recapitulates phenotype of human patients. These animals, show early prenatal origin and age-dependent progression of the disease.
Cat. #: 160590
Research Fields: Immunology
Target: Monocyte Chemoattractant Protein-1-Induced Protein-1
Disease: Human primary biliary cholangitis
Model: Knock-Out
Phenotype: Adapted from Kotlinowski J. et al. bioRxiv; 2020. DOI: 10.1101/2020.09.05.250522:This mouse model was developed to verify whether Mcpip1 expression protects against development of PBC. Deletion of hepatic Mcpip1 in Mcpip1AlbKO mice leads to development of PBC that recapitulates phenotype of human patients. These animals, show early prenatal origin and age-dependent progression of the disease.
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Deletion of Mcpip1 in Mcpip1AlbKO mice recapitulates the phenotype of human primary biliary cholangitis

Images

View Gallery
From Kotlinowski J. et al. bioRxiv; 2020. DOI

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.