ATF2 Flox Mouse

Conditional knockout of ATF2 DNA binding domain. Transcription factor (BZIP-type, AP1-family)

Contributors

Inventor Institute
Nic Jones Cancer Research UK, Manchester Institute
Cat. #: 151647
Research Fields: Cell biology;Cell signaling and signal transduction;Developmental biology;Genetics;Immunology
Target: ATF2
Model: Conditional KO
Zygosity: Homozygous
Phenotype: Homozygous normal phenotype
Product description: Conditional knockout of ATF2 DNA binding domain. Transcription factor (BZIP-type, AP1-family)
Conditional: Yes
Genetic background: Atf2 genomic sequences were isolated by screening a 129/ola mouse cosmid library, cloned into pPGKneobpAlox2PGKDlacZ-pA-neo-loxP, transfected into 129/ola embryonic stem cells and selected for G418 resistance. Transgenic animals were produced by blastocyst injection and offspring mice were backcrossed at least six times with C57 Bl/6 mice to produce isogenic lines.
Production details: Atf2 genomic sequences were isolated by screening a 129/ola mouse cosmid library, cloned into pPGKneobpAlox2PGKDlacZ-pA-neo-loxP, transfected into 129/ola embryonic stem cells and selected for G418 resistance. Transgenic animals were produced by blastocyst injection and offspring mice were backcrossed at least six times with C57 Bl/6 mice to produce isogenic lines.
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Breitwieser et al. 2007. Genes Dev. 21(16):2069-82. PMID: 17699753.

Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells.

Related Tools for Mouse models

Cat. # Tool Name
151454 Bmx Cre ERT2 Mouse Key Info View Tool
151474 DR3-/- KO Mouse Key Info View Tool
151520 CDH5(PAC)CreERT2 Mouse Key Info View Tool
151534 Pdgfrb-Cre Mouse Key Info View Tool
151549 Inva3b1 Mouse Key Info View Tool

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.