USP9x-deficient HCT116 (with or without p53) cell line

In this technology, the gene USP9X is knocked out of two the HCT116 cell line. The gene knockout has been performed by rAAV-mediated homologous recombination.

Contributors

Inventor Institute
Fred Bunz Johns Hopkins University
Cat. #: 156403
Tool sub type: Continuous
Unit size: 1×10^6 cells / vial
Cancer types: Colorectal cancer
Research Fields: Cancer;Drug development
Tissue: Colon
Model: Knock-Out
Product description: This cell line presents an opportunity to study the effect of loss of apoptotic control on colorectal cancer cells. Study of deubiquitinase Ups9X could act as a leap towards understanding apoptotic regulation and potentially lead to new drug targets for cancer.In this technology, the gene USP9X is knocked out of two the HCT116 cell line. The gene knockout has been performed by rAAV-mediated homologous recombination. The technology also consists of a double knockout line without USP9X and p53, a tumor suppressor gene.
Parental cell line: HCT 116
Disease: Cancer
Format: Frozen
Shipping conditions: Dry ice
References:

Harris et al. 2012. Cancer Biol Ther. 13(13):1319-24. PMID: 22895071.

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