#156403

USP9x-deficient HCT116 (with or without p53) cell line

Cat. #156403

USP9x-deficient HCT116 (with or without p53) cell line

Cat. #: 156403

Sub-type: Continuous

Unit size: 1x10^6 cells / vial

Tissue: Colon

Disease: Cancer

Model: Knock-Out

£575.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Fred Bunz

Institute: Johns Hopkins University

Tool Details
Target Details
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: USP9x-deficient HCT116 (with or without p53) cell line
  • Tool sub type: Continuous
  • Parental cell: HCT 116
  • Tissue: Colon
  • Disease: Cancer
  • Model: Knock-Out
  • Description: This cell line presents an opportunity to study the effect of loss of apoptotic control on colorectal cancer cells. Study of deubiquitinase Ups9X could act as a leap towards understanding apoptotic regulation and potentially lead to new drug targets for cancer.In this technology, the gene USP9X is knocked out of two the HCT116 cell line. The gene knockout has been performed by rAAV-mediated homologous recombination. The technology also consists of a double knockout line without USP9X and p53...

Target Details

  • Target: USP9X and p53

Handling

  • Format: Frozen
  • Unit size: 1x10^6 cells / vial
  • Shipping conditions: Dry ice

References

  • Harris et al. 2012. Cancer Biol Ther. 13(13):1319-24. PMID: 22895071.