Cat. #156405
R-3327-AT6.1 cell line
Cat. #: 156405
Unit size: 1x10^6 cells / vial
Availability: 10-12 weeks
Disease: Cancer
Model: Cancer Model
£575.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: John Isaacs
Institute: Johns Hopkins University
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: R-3327-AT6.1 cell line
- Cancer: Genitourinary cancer
- Cancers detailed: Prostate
- Research fields: Cancer;Drug development
- Disease: Cancer
- Model: Cancer Model
- Description: Somatic cell hybrids created from highly metastatic rat prostatic cancer cells and human chromosome 11 were created using micro cell-mediated chromosome transfer. The introduction of human chromosome 11 into the highly metastatic rat prostate cancer cells suppressed the metastatic ability of the cells without suppression of the in vivo growth rate or tumorigenicity of the hybrid cells.These cell hybrids can be used to pinpoint tumor suppressor genes on human chromosome 11. The cell line may also be used to screen for drugs that target the human tumor suppressor genes expressed. Such drugs can potentially be used as chemotherapeutic or chemopreventive agents for prostate cancer.
- Cellosaurus id: CVCL_4030
Target Details
- Target: Tumor suppressor genes on Human chromosome 11
Handling
- Format: Frozen
- Unit size: 1x10^6 cells / vial
- Shipping conditions: Dry ice
References
- Ichikawa et al. 1992. Cancer Res. 52(12):3486-90. PMID: 1596907.
