Melb-s2 cell line
Organism: Mouse
Tissue: Skin
Disease: Non-cancer
Model: Immortalised non-cancerous cell lines
£575.00
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Contributor
Inventor: Elena Sviderskaya
Institute: St. George's University London
Primary Citation: Sviderskaya EV, et al. Dev Dyn. 1998 Dec;213(4):452-63. PMID: 9853966
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Melb-s2 cell line
- Cancer: N/A
- Research fields: Tissue-specific biology
- Organism: Mouse
- Gender: Unspecified
- Tissue: Skin
- Disease: Non-cancer
- Morphology: Small, oval-fusiform
- Growth properties: Adherent
- Model: Immortalised non-cancerous cell lines
- Crispr: No
- Conditional: No
- Description: The melb-s1, -s2 and s3 lines are immortal melanoblast cell lines derived from the skin of neonatal Ednrbs/Ednrbs C3H mice. These cells express dopachrome tautomerase (also referred to as tyrosinase-related protein 2) but generally do not express tyrosinase. These cells are unpigmented. Melanocytes, irreversibly differentiated from melb-s1 melanoblasts (melan-s1) are also available from CancerTools.org. This melanoblast line is useful for developmental studies and, as melanoblasts display mechanisms similar to tumour cells (migration to and invasion of the epidermis) they may be a useful tool in studies of melanoma development.
- Application: Melanocyte cell biology
- Biosafety level: BSL1
Applications
- Application: Melanocyte cell biology
Handling
- Growth medium: RPMI + FBS (10%) + fibroblast growth factor 2 (FGF2) (40 pM) + mouse stem cell factor (mSCF) (20 ng/ml)
- Storage conditions: liquid N2
References
- Sviderskaya EV, et al. Dev Dyn. 1998 Dec
- 213(4):452-63. PMID: 9853967
