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#162005

Melan-lnk4a-Arf-b1 cell line

Cat. #162005

Melan-lnk4a-Arf-b1 cell line

Cat. #: 162005

Availability: 8-10 weeks

Organism: Mouse

Tissue: Skin

Model: Immortalised non-cancerous cell lines

£575.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Elena Sviderskaya

Institute: St. George's University London

Primary Citation: Sviderskaya EV, et al. J Natl Cancer Inst. 2002 Mar 20;94(6):446-54. PMID: 11904317

Tool Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Melan-lnk4a-Arf-b1 cell line
  • Organism: Mouse
  • Tissue: Skin
  • Morphology: Small, oval-fusiform
  • Model: Immortalised non-cancerous cell lines
  • Description: The melan-Ink4a-Arf-b1, -b2 and -b3 cell lines are immortal melanocyte cell lines derived from the skin of neonatal Tyrp1b/Tyrp1b Ink4aArf -/- C57BL/6J mice. These melanocytes do not express the melanogenic enzyme tyrosinase-related protein 1 (Tyrp1), or p16Ink4A and Arf. These melanocytes display brown pigmentation in culture which is reduced compared to cell lines that have functional Tyrp1 but are derived from Ink4aArf -/- C57BL/6J mice (such as melan-Ink4a-Arf-1,-2, -3 and -4 which are also available from CancerTools.org. These melanocytes can be used as a model of Tyrp1-null skin melanocytes in studies focussing on skin cancers and melanomas. They are also a useful tool for studies of pigmentation genetics.
  • Application: Melanocyte cell biology

Applications

  • Application: Melanocyte cell biology

Handling

  • Growth medium: RPMI + FBS (10%) + TPA (200 nM) + cholera toxin (CT) (200 pM)
  • Storage conditions: liquid N2

References

  • Sviderskaya EV, et al. J Natl Cancer Inst. 2002 Mar 20
  • 94(6):446-54. PMID: 11904317

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