Antibody to acetylated histine H4. Specificity: Acetylated histone H4 at positions K5, K8, K12 or K16. Acetylation of histone H4 is an epigenetic modification often associated with transcriptional activation.
| Institute |
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| Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) |
| Cat. #: | 162392 |
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| Research Fields: | Epigenetics and Nuclear signalling |
| Application: | ELISA, WB, IP, IF |
| Target: | acetyl Histone H4 |
| Reactivity: | Sequence conserved in wide range of species |
| Clone: | 3HH4-2C2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, et al. (2001) Embo J 20: 3187-3196. |
| Product description: | Antibody to acetylated histine H4. Specificity: Acetylated histone H4 at positions K5, K8, K12 or K16. Acetylation of histone H4 is an epigenetic modification often associated with transcriptional activation. |
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| Additional notes: | Avoid repeat freezing and thawing cycles. Does not contain any preservative. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1, k |
| Immunogen: | synthetic peptide: MSGRG(acetyl-K)GG(acetyl-K)GLG(acetyl-K)GGA(acetylK)RHRKVLR-(C) corresponding to aa 1 to 24 of human histone H4. |
| Target background: | Acetylation of histone H4 is an epigenetic modification often associated with transcriptional activation. |
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| Storage conditions: | -20°C (up to 3 years) |
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| References: |
Dilworth FJ, Fromental-Ramain C, Yamamoto K, Chambon P. ATP-driven chromatin remodeling activity and histone acetyltransferases act sequentially during transactivation by RAR/RXR In vitro. Mol Cell. 2000. 6(5):1049-58 |
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