X-Ray Repair Cross Complementing 2 (XRCC2) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC2 is […]
| Inventor | Institute |
|---|---|
| Stephen West | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151273 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Genetics;Microbiology |
| Application: | WB |
| Target: | XRay Repair Cross Complementing 2 (XRCC2) |
| Reactivity: | Human |
| Clone: | XRCC2 7B7/3 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | X-Ray Repair Cross Complementing 2 (XRCC2) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC2 is also a component of the homologous recombination pathway. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 33 kDa |
| Immunogen: | His-tagged human XRCC2 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | X-Ray Repair Cross Complementing 2 (XRCC2) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC2 is also a component of the homologous recombination pathway. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Masson et al. 2001. Genes Dev. 15(24):3296-307. PMID: 11751635. Masson et al. 2001. Genes Dev. 15(24):3296-307. PMID: 11751635. Identification and purification of two distinct complexes containing the five RAD51 paralogs. Cartwright et al. 1998. Nucleic Acids Res. 26(13):3084-9. PMID: 9628903. The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family. |
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