Cat. #160856
Anti-troponin 1 [14] mAb
Cat. #: 160856
Sub-type: Primary antibody
Unit size: 100 ug
Target: Human Cardiac Troponin 1
Class: Monoclonal
Application: ELISA ; WB
Reactivity: Human ; Dog
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Peter Cummins
Institute: University Of Birmingham
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-troponin 1 [14] mAb
- Alternate name: CdTn1, cTn1
- Research fields: Tissue-specific biology
- Clone: 14
- Tool sub type: Primary antibody
- Class: Monoclonal
- Reactivity: Human ; Dog
- Application: ELISA ; WB
- Description: Cardiac and skeletal muscle contraction involves the cyclic interaction of myosin cross bridges with actin involving the concomitant hydrolysis of Mg ATP. Troponin and tropomyosin, located on the actin thin filament, are responsible for the calcium dependent regulation of the contractile process by responding to changes in the intracellular free calcium concentration. Muscle contraction is initiated by the binding of calcium to troponin C; this initiates a cascade of allosteric changes in the troponin/ tropomyosin complex, releasing the inhibitory troponin-I/actin interaction, and resulting in tropomyosin rotating radially on the thin filament from the inhibitory position. This allows actin and myosin to interact fully and, therefore, contraction to ensue.
- Immunogen: Canine and Human CdTn1
- Isotype: IgG1
- Recommended controls: IgG1
Target Details
- Target: Human Cardiac Troponin 1
Applications
- Application: ELISA ; WB
Handling
- Unit size: 100 ug
- Shipping conditions: Shipping at 4° C
References
- Al-Hillawi et al. 1998. Eur J Biochem. 256(3):535-40. PMID: 9780229.
- Cummins et al. 1987. Am Heart J. 113(6):1333-44. PMID: 3591601.
