Cat. #153528
Anti-STAT1 [ps727]
Cat. #: 153528
Unit size: 100 ug
Availability: 10-12 weeks
Target: Signal transducer and activator of transcription 1 phosphorylated at residue Serine 727
Class: Polyclonal
Application: IP ; WB ; EMSA
Reactivity: Human
Host: Rabbit
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Thomas Decker
Institute: University of Vienna
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-STAT1 [ps727]
- Alternate name: STAT1, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
- Research fields: Cell signaling and signal transduction
- Class: Polyclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Rabbit
- Application: IP ; WB ; EMSA
- Description: In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by several ligands such as Interferon alpha, Interferon gamma, Platelet Derived Growth Factor, Interleukin 6 or Epidermal Growth Factor. STAT1 has a key role in expressing many genes involved in survival of the cell, viability or pathogen response. Through alternative splicing there are two possible transcripts which encode 2 isoforms of STAT1. The compound, diallyl disulphide, found in garlic can induce STAT1 phosphorylation.
- Immunogen: keyhole limpet hemocyanin (KLH)-coupled phosphopeptide - sequence DNLLPMpSPEEFDE
Target Details
- Target: Signal transducer and activator of transcription 1 phosphorylated at residue Serine 727
- Target background: In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by several ligands such as Interferon alpha, Interferon gamma, Platelet Derived Growth Factor, Interleukin 6 or Epidermal Growth Factor. STAT1 has a key role in expressing many genes involved in survival of the cell, viability or pathogen response. Through alternative splicing there are two possible transcripts which encode 2 isoforms of STAT1. The compound, diallyl disulphide, found in garlic can induce STAT1 phosphorylation.
Applications
- Application: IP ; WB ; EMSA
Handling
- Format: Liquid
- Concentration: 0.9-1.1mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -80° C
- Shipping conditions: Shipping at 4° C
Related Tools
- Related tools: Anti-Stat1ÄÂ?-C, Polyclonal
References
- Kovarik et al. 1998. EMBO J. 17(13):3660-8. PMID: 9649436.