HD 8B6 has potential uses in the diagnosis of ovarian and testicular tumours. The antibody detects both Regan and Nagao isoenzymes.
| Inventor | Institute |
|---|---|
| Walter Bodmer | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151107 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology |
| Application: | IF ; ELISA ; IHC ; RIA |
| Target: | Placental Alkaline Phosphatase (PLAP), Regan and Nagao isoenzymes. |
| Reactivity: | Human |
| Clone: | HD 8B6 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | HD 8B6 has potential uses in the diagnosis of ovarian and testicular tumours. The antibody detects both Regan and Nagao isoenzymes. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | Fresh Hep-2 cells followed by booster injections of fresh Hep-2 cells that have had their surface expression of PLAP boosted in culture. |
| Immunogen Uniprot ID: | P05187 |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | Alkaline phosphatases are phosphodiesterases. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. The detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Sharp et al. 2010. PLoS One. 5(10):e13130. PMID: 20976190. Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. Wojtowicz et al. 2007. Cell. 130(6):1134-45. PMID: 17889655. A vast repertoire of Dscam binding specificities arises from modular interactions of variable Ig domains. Durbin et al. 1988. Int J Cancer Suppl. 2:50-8. PMID: 2450848. Durbin et al. 1988. Int J Cancer Suppl. 2:59-66. PMID: 3162446. Production of monoclonal antibodies to placental alkaline phosphatase: preliminary characterisation includes identification of one antibody reactive with routinely fixed histological preparations. Monoclonal antibodies to placental alkaline phosphatase: preclinical evaluation in a human xenograft tumour model of F(ab')2 and Fab fragments. |
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