Cat. #159686
Anti-PD-1H [MH5A]
Cat. #: 159686
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Programmed Death-1 Homolog
Class: Monoclonal
Application: IHC ; FACS
Reactivity: Mouse
Host: Hamster
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Leiping Chen
Institute: Yale University
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-PD-1H [MH5A]
- Alternate name: VISTA, Gi24, Dies1, B7-H5, DD1a
- Research fields: Cancer;Immunology
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Mouse
- Host: Hamster
- Application: IHC ; FACS
- Description: Programmed Death-1 Homolog (PD-1H) is a cell surface immunoglobulin super family molecule which is expressed constitutively on the surface of hematopoetic cells (T cells, NK cells, monocytes, and DCs) and regulates differentiation of osteoblast, adipocyte, and embryonic cells. It has also been shown to regulate cell apoptosis. PD-1H acts mainly as a coinhibitor in the T cell initiation of T cell responses to antigens and is critical for the differentiation and stability of inducible T regulatory cells. This antibody has been shown to prevent acute graft versus host disease (GVHD) in semi-and fully-allogeneic mouse models, resulting in full chimerism after treatment.
- Immunogen: mPD-1HIg fusion protein
- Myeloma used: Sp2/0
Target Details
- Target: Programmed Death-1 Homolog
- Target background: Programmed Death-1 Homolog (PD-1H) is a cell surface immunoglobulin super family molecule which is expressed constitutively on the surface of hematopoetic cells (T cells, NK cells, monocytes, and DCs) and regulates differentiation of osteoblast, adipocyte, and embryonic cells. It has also been shown to regulate cell apoptosis. PD-1H acts mainly as a coinhibitor in the T cell initiation of T cell responses to antigens and is critical for the differentiation and stability of inducible T regulatory cells. This antibody has been shown to prevent acute graft versus host disease (GVHD) in semi-and fully-allogeneic mouse models, resulting in full chimerism after treatment.
Applications
- Application: IHC ; FACS
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Dry ice
References
- Flies et al. 2011. J Immunol. 187(4):1537-41. PMID: 21768399.
