Cat. #153657
Anti-Omomyc [21-1-3]
Cat. #: 153657
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-5 days
Target: Omomyc
Class: Monoclonal
Application: ELISA ; IHC ; IF ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Laura Soucek
Institute: Vall D'Hebron Institute Of Oncology (VHIO)
Primary Citation: Soucek et al. 2004. Cell Death Differ. 11(9):1038-45. PMID: 15143346.
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Omomyc [21-1-3]
- Research fields: Apoptosis and autophagy;Cancer;Cell biology;Genetics
- Clone: 17
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; IHC ; IF ; WB
- Description: Monoclonal antibody specific for Omomyc, capable of suppressing Myc-induced oncogenesis. Omomyc is a dominant-negative allele of the proto-oncogene Myc (c-Myc). Omomyc is a mutant bHLHZip domain that sequesters Myc in complexes that are unable to bind to the E box recognition element and activate transcription but remain competent for transcriptional repression. Expression of Omomyc can induce rapid tumour regression in mouse models with little toxicity for normal tissues, acting as a suppressor of Myc-induced oncogenesis.
- Isotype: IgG2a kappa
Target Details
- Target: Omomyc
- Target background: Monoclonal antibody specific for Omomyc, capable of suppressing Myc-induced oncogenesis. Omomyc is a dominant-negative allele of the proto-oncogene Myc (c-Myc). Omomyc is a mutant bHLHZip domain that sequesters Myc in complexes that are unable to bind to the E box recognition element and activate transcription but remain competent for transcriptional repression. Expression of Omomyc can induce rapid tumour regression in mouse models with little toxicity for normal tissues, acting as a suppressor of Myc-induced oncogenesis.
Applications
- Application: ELISA ; IHC ; IF ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
- Shipping conditions: Shipping at 4° C
References
- MassĂł-VallĂŠs D et al. 2022. Cancer Res Commun. 2(2):110-130. PMID: 36860495.
- Fiorentino et al. 2016. Oncotarget. 7(21):31014-28. PMID: 27105536.
- Soucek et al. 2013. Genes Dev. 27(5):504-13. PMID: 23475959.
- Soucek et al. 2004. Cell Death Differ. 11(9):1038-45. PMID: 15143346.
