Cat. #151495
Anti-MUC1 [HMFG1]
Cat. #: 151495
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 1-2 weeks
Target: Mucin1 (MUC1)
Class: Monoclonal
Application: FACS ; ELISA ; FACS ; IHC ; IF ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Joyce Taylor-Papadimitriou ; Joy Burchell
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-MUC1 [HMFG1]
- Alternate name: ADMCKD, ADMCKD1, Breast carcinoma associated antigen DF3, Breast carcinoma-associated antigen DF3, CA 15-3, CA15 3, CA15 3 antigen, CA15.3, Cancer antigen 15-3, Carcinoma associated mucin, Carcinoma-associated mucin, CD 227, CD227
- Cancer: Breast cancer;Gynaecologic cancer
- Cancers detailed: Breast cancer;Broadly Applicable;Colon;Ovarian
- Research fields: Cancer;Cell biology;Cell signaling and signal transduction
- Clone: HMFG1
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: FACS ; ELISA ; FACS ; IHC ; IF ; WB
- Description: Mucin-1 (MUC1) is a membrane protein present on normal human breast epithelial cells and cell lines derived from breast carcinomas. Human MUC1 is also localised on the surface of the human milk fat globule. MUC1 is a differentiation marker and specific breast epithelial marker in normal and neoplastic mammary development. It is upregulated in the lactating breast and in carcinomas.
- Immunogen: Delipidated human milk fat globule.
- Isotype: IgG1
- Myeloma used: P3/NS1/1-Ag4.1
Target Details
- Target: Mucin1 (MUC1)
- Target background: Mucin-1 (MUC1) is a membrane protein present on normal human breast epithelial cells and cell lines derived from breast carcinomas. Human MUC1 is also localised on the surface of the human milk fat globule. MUC1 is a differentiation marker and specific breast epithelial marker in normal and neoplastic mammary development. It is upregulated in the lactating breast and in carcinomas.
Applications
- Application: FACS ; ELISA ; FACS ; IHC ; IF ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
Related Tools
- Related tools: Anti-MUC1 [HMFG2] ; Anti-MUC1, Recombinant [HMFG2]
References
- Burchell et al. 1993. Epithelial Cell Biol. 2(4):155-62. PMID: 7505698.
- Effect of modification of carbohydrate side chains on the reactivity of antibodies with core-protein epitopes of the MUC1 gene product.
- Moss et al. 1988. Lung Cancer. 4, 76-78.
- Burchell et al. 1987. Cancer Res. 47(20):5476-82. PMID: 2443241.
- Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin.
- Chang et al. 1986. Biochim Biophys Acta. 823(3):161-94. PMID: 2423124.
- In vitro transformation of human epithelial cells.
- Burchell et al. 1983. J Immunol. 131(1):508-13. PMID: 6190927.
- Complexity of expression of antigenic determinants, recognized by monoclonal antibodies HMFG-1 and HMFG-2, in normal and malignant human mammary epithelial cells.
- Taylor-Papadimitriou et al. 1981. Int J Cancer. 28(1):17-21. PMID: 7309278.
- Arklie et al. 1981. Int J Cancer. 28(1):23-9. PMID: 6273328.
- Differentiation antigens expressed by epithelial cells in the lactating breast are also detectable in breast cancers.
- Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: production and reaction with cells in culture.
