#151079

Anti-Microglobulin Beta2 [BBM.1]

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Cat. #151079

Anti-Microglobulin Beta2 [BBM.1]

Cat. #: 151079

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 1-2 weeks

Target: Microglobulin Beta 2

Class: Monoclonal

Application: ELISA ; FACS ; IHC ; IP ; Fn

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Walter Bodmer

Institute: University of Oxford

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-Microglobulin Beta2 [BBM.1]
  • Research fields: Cancer;Tissue-specific biology
  • Clone: BBM.1
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Strain: Balb/c
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; FACS ; IHC ; IP ; Fn
  • Description: BBM.1 binds significantly with fibroblasts and lymphocytes from humans and primates and can be used for the detection of Beta2-microglobulin in myeloma and other conditions (serum assay kits etc.). BBM.1 binds equivalently to free and HLA-associated Beta2-microglobulin and may be used for detection in myeloma and other conditions (e.g. within serum assay kits).
  • Immunogen: Molt 4, a human T cell line.
  • Isotype: IgG2b
  • Myeloma used: P3X63Ag8

Target Details

  • Target: Microglobulin Beta 2
  • Target background: Beta2-microglobulin associates with human leucocyte antigens (HLAs).

Applications

  • Application: ELISA ; FACS ; IHC ; IP ; Fn

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • Novoselov et al. 2012. Virus Res. 166(1-2):87-96. PMID: 22445689.
  • Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells.
  • A single amino acid substitution controls DAF-dependent phenotype of echovirus 11 in rhabdomyosarcoma cells.
  • Josson et al. 2011. Cancer Res. 71(7):2600-10. PMID: 21427356.
  • ?2-microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells.
  • Du et al. 2009. J Mol Recognit. 22(6):465-73. PMID: 19582797.
  • Parham et al. 1983. J Biol Chem. 258(10):6179-86. PMID: 6189821.
  • Arginine 45 is a major part of the antigenic determinant of human beta 2-microglobulin recognized by mouse monoclonal antibody BBM.1.
  • Brodsky et al. 1979. Immunol Rev. 47:3-61. PMID: 95015.
  • Brodsky et al. 1979. Eur J Immunol. 9(7):536-45. PMID: 91522.
  • Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens.
  • Monoclonal antibodies for analysis of the HLA system.