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Cat. #151079
Anti-Microglobulin Beta2 [BBM.1]
Cat. #: 151079
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Microglobulin Beta 2
Class: Monoclonal
Application: ELISA ; FACS ; IHC ; IP ; Fn
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Walter Bodmer
Institute: University of Oxford
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Microglobulin Beta2 [BBM.1]
- Research fields: Cancer;Tissue-specific biology
- Clone: BBM.1
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; FACS ; IHC ; IP ; Fn
- Description: BBM.1 binds significantly with fibroblasts and lymphocytes from humans and primates and can be used for the detection of Beta2-microglobulin in myeloma and other conditions (serum assay kits etc.). BBM.1 binds equivalently to free and HLA-associated Beta2-microglobulin and may be used for detection in myeloma and other conditions (e.g. within serum assay kits).
- Immunogen: Molt 4, a human T cell line.
- Isotype: IgG2b
- Myeloma used: P3X63Ag8
Target Details
- Target: Microglobulin Beta 2
- Target background: Beta2-microglobulin associates with human leucocyte antigens (HLAs).
Applications
- Application: ELISA ; FACS ; IHC ; IP ; Fn
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Dry ice
References
- Novoselov et al. 2012. Virus Res. 166(1-2):87-96. PMID: 22445689.
- Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells.
- A single amino acid substitution controls DAF-dependent phenotype of echovirus 11 in rhabdomyosarcoma cells.
- Josson et al. 2011. Cancer Res. 71(7):2600-10. PMID: 21427356.
- ?2-microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells.
- Du et al. 2009. J Mol Recognit. 22(6):465-73. PMID: 19582797.
- Parham et al. 1983. J Biol Chem. 258(10):6179-86. PMID: 6189821.
- Arginine 45 is a major part of the antigenic determinant of human beta 2-microglobulin recognized by mouse monoclonal antibody BBM.1.
- Brodsky et al. 1979. Immunol Rev. 47:3-61. PMID: 95015.
- Brodsky et al. 1979. Eur J Immunol. 9(7):536-45. PMID: 91522.
- Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens.
- Monoclonal antibodies for analysis of the HLA system.
