Anti-Microglobulin Beta2 [BBM.1]

BBM.1 binds significantly with fibroblasts and lymphocytes from humans and primates and can be used for the detection of Beta2-microglobulin in myeloma and other conditions (serum assay kits etc.). BBM.1 binds equivalently to free and HLA-associated Beta2-microglobulin and may be used for detection in myeloma and other conditions (e.g. within serum assay kits).

Contributors

Inventor Institute
Walter Bodmer University of Oxford
Cat. #: 151079
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Tissue-specific biology
Application: ELISA ; FACS ; IHC ; IP ; Fn
Target: Microglobulin Beta 2
Reactivity: Human
Clone: BBM.1
Host: Mouse
Class: Monoclonal
Product description: BBM.1 binds significantly with fibroblasts and lymphocytes from humans and primates and can be used for the detection of Beta2-microglobulin in myeloma and other conditions (serum assay kits etc.). BBM.1 binds equivalently to free and HLA-associated Beta2-microglobulin and may be used for detection in myeloma and other conditions (e.g. within serum assay kits).
Conjugation: Unconjugated
Isotype: IgG2b
Immunogen: Molt 4, a human T cell line.
Myeloma used: P3X63Ag8
Target background: Beta2-microglobulin associates with human leucocyte antigens (HLAs).
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Novoselov et al. 2012. Virus Res. 166(1-2):87-96. PMID: 22445689.

Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells.

A single amino acid substitution controls DAF-dependent phenotype of echovirus 11 in rhabdomyosarcoma cells.

Josson et al. 2011. Cancer Res. 71(7):2600-10. PMID: 21427356.

?2-microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells.

Du et al. 2009. J Mol Recognit. 22(6):465-73. PMID: 19582797.

Parham et al. 1983. J Biol Chem. 258(10):6179-86. PMID: 6189821.

Arginine 45 is a major part of the antigenic determinant of human beta 2-microglobulin recognized by mouse monoclonal antibody BBM.1.

Brodsky et al. 1979. Immunol Rev. 47:3-61. PMID: 95015.

Brodsky et al. 1979. Eur J Immunol. 9(7):536-45. PMID: 91522.

Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens.

Monoclonal antibodies for analysis of the HLA system.

Images

View Gallery

Related Tools for Antibodies

Cat. # Tool Name
151017 Anti-MBP [R29.6] Key Info View Tool
151026 Anti-FCGR1 [10.1] mAb Key Info View Tool
151034 Anti-HSVUL42 [13D11] Key Info View Tool
151036 Anti-ICAM1 [15.2] Key Info View Tool
151039 Anti-Integrin aVb3 [23C6] Key Info View Tool

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.