#152747

Anti-JMY [HMY117]

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Cat. #152747

Anti-JMY [HMY117]

Cat. #: 152747

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-4 weeks

Target: JMY

Class: Monoclonal

Application: IHC ; WB

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

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Contributor

Inventor: Helen Turley

Institute: University of Oxford

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-JMY [HMY117]
  • Research fields: Apoptosis and autophagy
  • Clone: HMY117
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IHC ; WB
  • Description: The anti-JMY [HMY117] antibody recognises uman JMY. JMY is a p300-binding protein with dual action: by enhancing P53 transcription in the nucleus, it plays an important role in the cellular response to DNA damage, while by promoting actin filament assembly in the cytoplasm; it induces cell motility in vitro. It might act either as tumor suppressor or as oncogene. This antibody may be used in research but also as a diagnostic tool.
  • Immunogen: Synthetic peptide from the c terminus of the peptide sequence, identical for both isoform 1 and 2
  • Isotype: IgG1
  • Myeloma used: P3/NS1/1-Ag4.1
  • Recommended controls: MCF7, HeLa

Target Details

  • Target: JMY
  • Tissue cell line specificity: MCF7, HeLa
  • Target background: The anti-JMY [HMY117] antibody recognises uman JMY. JMY is a p300-binding protein with dual action: by enhancing P53 transcription in the nucleus, it plays an important role in the cellular response to DNA damage, while by promoting actin filament assembly in the cytoplasm; it induces cell motility in vitro. It might act either as tumor suppressor or as oncogene. This antibody may be used in research but also as a diagnostic tool.

Applications

  • Application: IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Dry ice

References

  • Adighibe et al. 2014. Virchows Arch. 465(6):715-22. PMID: 25280461.
  • JMY protein, a regulator of P53 and cytoplasmic actin filaments, is expressed in normal and neoplastic tissues.

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