Cat. #151367
Anti-Integrin b3 [Y2/51] mAb
Cat. #: 151367
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Integrin ?3 (CD61; GPIIIa)
Class: Monoclonal
Application: FACS ; IHC ; IF ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Jacqueline Cordell
Institute: University of Oxford
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Integrin b3 [Y2/51] mAb
- Alternate name: Integrin Subunit Beta; Integrin; Beta 3 (Platelet Glycoprotein IIIa; Antigen CD61); Platelet Membrane Glycoprotein IIIa; Antigen CD61; GPIIIa; GP3A; Platelet Glycoprotein IIIa; Integrin Beta 3; CD61 Antigen; BDPLT16; BDPLT2; CD61; GT
- Research fields: Cell biology;Cell signaling and signal transduction;Tissue-specific biology
- Clone: Y2/51
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: FACS ; IHC ; IF ; WB
- Description: Monoclonal antibody which can detect CD61 marker on megakaryocytes.
- Immunogen: Phytohaemagglutin-stimulated peripheral blood cells
- Immunogen uniprot id: P05106
- Isotype: IgG1
- Myeloma used: P3/NS1/1-Ag4.1
Target Details
- Target: Integrin ?3 (CD61; GPIIIa)
- Target background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells and aberrant integrin expression has been found in many epithelial tumours. CD61/ integrin b3 is a glycoprotein found on megakaryocytes, osteoclasts, platelets and their precursors. CD61 antigen plays a role in platelet aggregation and also as a receptor for fibrinogen, fibronectin, von Willebrand factor and vitronectrin. This antibody is widely used as a marker of megakaryocytes in bone marrow trephines.
Applications
- Application: FACS ; IHC ; IF ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
- Shipping conditions: Shipping at 4° C
Related Tools
- Related tools: Anti-Integrin b3 [Y2/51] recombinant antibody
References
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- Silasi et al. 2019. Blood Adv. 3(4):658-669. PMID: 30808684.
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- Kahr et al. 2017. Nat Commun. 8:14816. PMID: 28368018.
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- Brune et al. 2007. Eur Cell Mater. 14:78-90
- discussion 90-1. PMID: 18085506.
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- The immunohistological detection of platelets, megakaryocytes and thrombi in routinely processed specimens.
- Vinci et al. 1984. Br J Haematol. 56(4):589-605. PMID: 6231944.
- Immunological study of in vitro maturation of human megakaryocytes.
- Nachman et al. 1982. J Clin Invest. 69(2):263-9. PMID: 6460044.
- Complex formation of platelet membrane glycoproteins IIb and IIIa with fibrinogen.
