Cat. #157673
Anti-HDAC6-D1 (236) mouse (D1 domain-specific)
Cat. #: 157673
Sub-type: Primary antibody
Unit size: 100 ug
Target: epitope in D1 domain of human histone deacetylase 6
Class: Monoclonal
Application: ELISA ; IHC ; IP ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: Institute of Biotechnology CAS
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-HDAC6-D1 (236) mouse (D1 domain-specific)
- Alternate name: Histone deacetylase 6; HD6
- Research fields: Cell biology;Genetics
- Tool sub type: Primary antibody
- Class: Monoclonal
- Purpose: Marker
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; IHC ; IP ; WB
- Description: The affinity purified mouse monoclonal antibody is immunospecific for the D1 domain of human histone deacetylase 6 (HDAC6) as determined by ELISA and peptide library screening. Reactivity of the mAb to homologous proteins from other species has not been tested. HDAC6 belongs to the class II of the histone deacetylase family (EC 3.5.1.98). The protein of molecular mass 131 kDa consists of two catalytic domains, the serine-glutamate-rich SE14 domain and the ubiquitin-binding ZnF domain. HDAC6 shuttles between the nucleus and the cytoplasm, but its localization is predominantly cytoplasmic. The enzyme deacetylates various substrates including ÄÂ?-tubulin, HSP90, cortactin, histones and other proteins. Described protein plays an important role in microtubule-dependent cell motility, apoptosis, cell signaling and transcriptional regulation, protein degradation, immune response and DNA repair. HDAC6 is linked to several neuronal diseases and carcinogenesis.
- Immunogen: human histone deacetylase 6 (HDAC6; sequence NP_006035.2)
- Immunogen uniprot id: Q9UBN7
- Isotype: IgG
Target Details
- Target: epitope in D1 domain of human histone deacetylase 6
- Tissue cell line specificity: Mouse
- Target background: The affinity purified mouse monoclonal antibody is immunospecific for the D1 domain of human histone deacetylase 6 (HDAC6) as determined by ELISA and peptide library screening. Reactivity of the mAb to homologous proteins from other species has not been tested. HDAC6 belongs to the class II of the histone deacetylase family (EC 3.5.1.98). The protein of molecular mass 131 kDa consists of two catalytic domains, the serine-glutamate-rich SE14 domain and the ubiquitin-binding ZnF domain. HDAC6 s...
Applications
- Application: ELISA ; IHC ; IP ; WB
Handling
- Format: Liquid
- Unit size: 100 ug
- Shipping conditions: Shipping at 4° C
