Anti-Estrogen Receptor Beta5 [PPG5/25]

Clone PPG5/25 recognizes Estrogen Receptor Beta (ER?) 5 and is useful in determining the expression of ER?5 in cancer cells, mainly via immunohistochemistry.

Contributors

Institute
BioServ UK Ltd
Cat. #: 153633
Tool sub type: Primary antibody
Unit size: 100 ug
Cancer types: Ovarian cancer, Breast cancer
Research Fields: Cancer;Immunology;Neurobiology
Application: IHC ; IF ; WB
Target: Estrogen Receptor ? 5
Reactivity: Human
Clone: PPG5/25
Host: Mouse
Class: Monoclonal
Alternate name: Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2
Product description: Estrogen receptors are commonly over-expressed in cancers. Clone PPG5/25 recognizes Estrogen Receptor Beta (ERÎ?) 5 and is useful in determining the expression of ERÎ?5 in cancer cells, mainly via immunohistochemistry.
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: Tuberculin conjugated peptide that recognizes C terminus of ER?5 at sequence LLSHVRHARYAP
Myeloma used: Sp2/0-Ag14
Target background: Estrogen receptors are commonly over-expressed in cancers. Clone PPG5/25 recognizes Estrogen Receptor Beta (ER?) 5 and is useful in determining the expression of ER?5 in cancer cells, mainly via immunohistochemistry.
Format: Liquid
Storage conditions: -80° C
Shipping conditions: Dry ice
References:

Zannoni et al. 2016. Histopathology. 68(4):541-8. PMID: 26132417.

Li et al. 2015. Oncol Lett. 10(4):2341-2346. PMID: 26622848.

Sexual dimorphism in medulloblastoma features.

Cytoplasm estrogen receptor ?5 as an improved prognostic factor in thymoma and thymic carcinoma progression.

Gender effect in experimental models of human medulloblastoma: does the estrogen receptor ? signaling play a role?

Ciucci et al. 2014. PLoS One. 9(7):e101623. PMID: 25000562.

Collins et al. 2009. BMC Cancer. 9:330. PMID: 19758455.

Expression of oestrogen receptors, ERalpha, ERbeta, and ERbeta variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERalpha.

Wong et al. 2005. J Pathol. 207(1):53-60. PMID: 15954165.

ERbeta isoform expression in colorectal carcinoma: an in vivo and in vitro study of clinicopathological and molecular correlates.

Images

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Clone PPG5/25 used to detect ER?5 expression thymic tumors by Immunofluorescence. (A)Overexpression of cytoplasmic ER?5 was observed in thymic carcinomas and thymomas; compared with the normal thymic tissues. (B) ER?5 expression was observed in the T1682 and TC1889 cell lines through indirect immunofluorescence. (C) The results revealed that the mean level of ER?5 gene expression was lower in advanced clinical stages. ER?5; estrogen receptor ?5. Source

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