Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 binds to XPF to form the heterodimer ERCC1-XPF, which is a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5′ of the DNA lesion). Some publications report […]
| Inventor | Institute |
|---|---|
| Julian Gannon | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151050 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Genetics |
| Application: | IF ; IP ; WB |
| Target: | ERCC1 |
| Reactivity: | Human |
| Clone: | ERCC1 3H11 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Cyclin-Dependent Kinase 1; Cell Division Cycle 2, G1 To S And G2 To M; Cell Division Control Protein 2 Homolog; Cell Division Protein Kinase 1; P34 Protein Kinase; P34CDC2; CDC28A; CDC2; Cell Cycle Controller CDC2; CDKN1 |
|---|---|
| Product description: | Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 binds to XPF to form the heterodimer ERCC1-XPF, which is a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5' of the DNA lesion). Some publications report that ERCC1 is elevated in cisplatin-resistant cells. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 33-36 |
| Immunogen: | Full length HIS-tagged recombinant human ERCC1 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 binds to XPF to form the heterodimer ERCC1-XPF, which is a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5' of the DNA lesion). Some publications report that ERCC1 is elevated in cisplatin-resistant cells. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
HCMV-infected cells maintain efficient nucleotide excision repair of the viral genome while abrogating repair of the host genome. O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410. Bhagwat et al. 2009. Cancer Res. 69(17):6831-8. PMID: 19723666. Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue. Biggerstaff et al. 1993. EMBO J. 12(9):3685-92. PMID: 8253090. Co-correction of the ERCC1, ERCC4 and xeroderma pigmentosum group F DNA repair defects in vitro. |
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| 151015 | Anti-CyclinA [E70.1] |
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| 151017 | Anti-MBP [R29.6] |
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Anti-MBP [R29.6]
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| 151025 | Anti-Vascular endothelium [10] |
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| 151027 | Anti-HSVICP8 [10A3] |
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Anti-HSVICP8 [10A3]
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| 151039 | Anti-Integrin aVb3 [23C6] |
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Anti-Integrin aVb3 [23C6]
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