Anti-ErbB3 [RTJ2] is a monoclonal antibody which binds ErbB3. ErbB3 (c-erbB-3/HER-3) is a type I growth factor receptor and binds to ligands in the heregulin family. ErbB3 is over-expressed in a variety of tumours in the bladder, breast, colon, pancreas and stomach._x000D_ _x000D_ By immunoprecipitation, this antibody detects a protein representing HER-3 from human tissue […]
| Inventor | Institute |
|---|---|
| Bill Gullick | University College London (UCL), UK |
| Cat. #: | 151158 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Cell signaling and signal transduction |
| Application: | ELISA ; FACS ; IHC ; IF ; IP ; WB |
| Target: | ErbB3 (Her3) |
| Reactivity: | Human |
| Clone: | RTJ2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Benterud et al. 1976. Tidsskr Nor Laegeforen. 96(31):1647-1648. PMID: 982398. |
| Alternate name: | Anti-ErbB3 antibody |
|---|---|
| Product description: | Anti-ErbB3 [RTJ2] is a monoclonal antibody which binds ErbB3. ErbB3 (c-erbB-3/HER-3) is a type I growth factor receptor and binds to ligands in the heregulin family. ErbB3 is over-expressed in a variety of tumours in the bladder, breast, colon, pancreas and stomach. By immunoprecipitation, this antibody detects a protein representing HER-3 from human tissue extracts. This antibody has also been used in immunohistochemistry, immunofluorescence, western blotting and ELISA procedures using human tissues. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Synthetic peptide of human ErbB3 |
| Immunogen Uniprot ID: | P21860 |
| Myeloma used: | NS0 |
| Target background: | The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). c-erbB3 is normally found in non-dividing differentiated epithelial cells, neurones and hepatocytes. It has approximately 80% prevalence in a wide variety of tumours of the gastro-intestinal tract, and approximately 20% prevalence in breast cancer. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Almadori et al. 2010. Eur J Cancer. 46(6):1144-1152. PMID: 20149638. Anagnostou et al. 2010. Cancer Epidemiol Biomarkers Prev. 19(4):982-991. PMID: 20332259. Okwueze et al. 2007. J Invest Dermatol. 127(5):1030-1041. PMID: 17124505. Srinivasan et al. 1998. J Pathol. 185(3):236-245. PMID: 9771476. Rajkumar et al. 1995. Int J Oncol. 6(1):105-109. PMID: 21556509. Benterud et al. 1976. Tidsskr Nor Laegeforen. 96(31):1647-1648. PMID: 982398. |
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