Cat. #151158
Anti-ErbB3 [RTJ2] mAb
Cat. #: 151158
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: ErbB3 (Her3)
Class: Monoclonal
Application: ELISA ; FACS ; IHC ; IF ; IP ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Bill Gullick
Institute: University College London (UCL), UK
Primary Citation: Benterud et al. 1976. Tidsskr Nor Laegeforen. 96(31):1647-1648. PMID: 982398.
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-ErbB3 [RTJ2] mAb
- Alternate name: Anti-ErbB3 antibody
- Research fields: Cancer;Cell biology;Cell signaling and signal transduction
- Clone: RTJ2
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; FACS ; IHC ; IF ; IP ; WB
- Description: Anti-ErbB3 [RTJ2] is a monoclonal antibody which binds ErbB3. ErbB3 (c-erbB-3/HER-3) is a type I growth factor receptor and binds to ligands in the heregulin family. ErbB3 is over-expressed in a variety of tumours in the bladder, breast, colon, pancreas and stomach. By immunoprecipitation, this antibody detects a protein representing HER-3 from human tissue extracts. This antibody has also been used in immunohistochemistry, immunofluorescence, western blotting and ELISA procedures using human tissues.
- Immunogen: Synthetic peptide of human ErbB3
- Immunogen uniprot id: P21860
- Isotype: IgG1
- Myeloma used: NS0
Target Details
- Target: ErbB3 (Her3)
- Target background: The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). c-erbB3 is normally found in non-dividing differentiated epithelial cells, neurones and hepatocytes. It has approximately 80% prevalence in a wide variety of tumours of the gastro-intestinal tract, and approximately 20% prevalence in breast cancer.
Applications
- Application: ELISA ; FACS ; IHC ; IF ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Dry ice
References
- Almadori et al. 2010. Eur J Cancer. 46(6):1144-1152. PMID: 20149638.
- Anagnostou et al. 2010. Cancer Epidemiol Biomarkers Prev. 19(4):982-991. PMID: 20332259.
- Okwueze et al. 2007. J Invest Dermatol. 127(5):1030-1041. PMID: 17124505.
- Srinivasan et al. 1998. J Pathol. 185(3):236-245. PMID: 9771476.
- Rajkumar et al. 1995. Int J Oncol. 6(1):105-109. PMID: 21556509.
- Benterud et al. 1976. Tidsskr Nor Laegeforen. 96(31):1647-1648. PMID: 982398.
