Cat. #157879
Anti-EEA1 [1G11]
Cat. #: 157879
Sub-type: Primary antibody
Unit size: 100 ug
Target: EEA1 (Early endosome antigen)
Class: Monoclonal
Application: IF ; WB
Reactivity: Human ; Rabbit
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Martin Fritzler
Institute: University of Calgary
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-EEA1 [1G11]
- Alternate name: MST15; MSTP15; ZFYVE2; early endosome antigen 1; early endosome antigen 1, 162kD; early endosome-associated protein; Endosome-associated protein p162; MSTP15; ZFYVE2; ZFYVE2MST15; Zinc finger FYVE domain-containing protein 2
- Research fields: Cell biology
- Tool sub type: Primary antibody
- Class: Monoclonal
- Purpose: Marker
- Conjugation: Unconjugated
- Molecular weight: 162 kDa
- Reactivity: Human ; Rabbit
- Host: Mouse
- Application: IF ; WB
- Description: Endosomes are cytoplasmic membrane-bound vesicles that function in the sorting and delivery of internalized material from the cell surface and the transport of materials from the golgi. Formed via endocytosis, endosomes can be classified by their gross morphology: early endosomes are composed of dynamic tubules whereas late endosomes are spherical with multiple internal vesicles. In neurons, early endosomes are involved in recycling of synaptic vesicles and neurotransmitter receptors. Early endosome antigen 1 (EEA1), a peripheral membrane protein associated with the cytoplasmic face of early endosomes, controls vesicle fusion during endocytosis. EEA1 is involved in neuronal synaptic vesicle function and axonal transport and growth. Autoantibodies directed against the 160 kDa EEA1 protein are seen in patients diagnosed with neurological and autoimmune conditions
- Immunogen: Recombinant protein
- Recommended controls: IgG1
Target Details
- Target: EEA1 (Early endosome antigen)
- Molecular weight: 162 kDa
- Tissue cell line specificity: Mouse
- Target background: Endosomes are cytoplasmic membrane-bound vesicles that function in the sorting and delivery of internalized material from the cell surface and the transport of materials from the golgi. Formed via endocytosis, endosomes can be classified by their gross morphology: early endosomes are composed of dynamic tubules whereas late endosomes are spherical with multiple internal vesicles. In neurons, early endosomes are involved in recycling of synaptic vesicles and neurotransmitter receptors. Early...
Applications
- Application: IF ; WB
Handling
- Format: Liquid
- Unit size: 100 ug
- Shipping conditions: Shipping at 4° C
References
- Selak et al. 2006. Neuroscience. 143(4):953-64. PMID: 17113235.
- Selak et al. 2004. Biochem Biophys Res Commun. 323(4):1334-42. PMID: 15451443.
- Selak et al. 2004. BMC Neurosci. 5:2. PMID: 14728723.
- Selak et al. 2003. Clin Immunol. 109(2):154-64. PMID: 14597214.
