Patients with rheumatoid arthritis, an inflammatory disease associated with increased microparticle production, have raised plasma levels of microparticles that expressed CLEC-2 but not GPVI. CLEC-2 can be used to monitor platelet-derived microparticles. The observation that microparticles derived from activated platelets retain CLEC-2 but lose GPVI highlights the potential use of measurement of surface expression of […]
| Inventor | Institute |
|---|---|
| Steve Watson | University of Birmingham |
| Cat. #: | 151914 |
|---|---|
| Unit size: | 100 ug |
| Research Fields: | Immunology;Tissue-specific biology |
| Application: | WB |
| Target: | C-type lectin-like receptor 2, CLEC1b |
| Reactivity: | Human papilloma virus |
| Clone: | AYP2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Patients with rheumatoid arthritis, an inflammatory disease associated with increased microparticle production, have raised plasma levels of microparticles that expressed CLEC-2 but not GPVI. CLEC-2 can be used to monitor platelet-derived microparticles. The observation that microparticles derived from activated platelets retain CLEC-2 but lose GPVI highlights the potential use of measurement of surface expression of platelet receptors to screen for platelet activation in a wide variety of cardiovascular and inflammatory diseases. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Molecular weight: | 26 kDa |
| Immunogen: | A recombinant extracellular fragment of human CLEC-2 (aa 68-229), which is the extracellular domain of the protein. |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Patients with rheumatoid arthritis, an inflammatory disease associated with increased microparticle production, have raised plasma levels of microparticles that expressed CLEC-2 but not GPVI. CLEC-2 can be used to monitor platelet-derived microparticles. The observation that microparticles derived from activated platelets retain CLEC-2 but lose GPVI highlights the potential use of measurement of surface expression of platelet receptors to screen for platelet activation in a wide variety of cardiovascular and inflammatory diseases. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | Hybridomas were cultured at 37? C and 96% relative humidity in air containing 6% CO2. Cells were grown in complete DMEM + Pen/strep + FCS was used at 10%. Cell density: Cells should be kept between 1-2×105 cells/ml and 5×105 cells/ml. |
| Storage conditions: | 4° C |
| Shipping conditions: | Dry ice |
| References: |
Gitz E et al, Blood, 2014. PMID: 25150298 |
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| 151027 | Anti-HSVICP8 [10A3] |
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| 151034 | Anti-HSVUL42 [13D11] |
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| 151036 | Anti-ICAM1 [15.2] |
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| 151037 | Anti-Cdk1 [17 (A17)] |
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