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Cat. #151464

Anti-Cisplatin modified DNA [CP9/19]

Cat. #: 151464

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-4 weeks

Target: Cisplatin modified native DNA

Class: Monoclonal

Application: ELISA ; FACS ; IHC ; IP ; DB

Host: Rat

£300.00

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Contributor

Inventor: Michael Tilby

Institute: The Institute of Cancer Research; Newcastle University

Tool Details

Target Details

Applications

Handling

Related Tools

References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

Name: Anti-Cisplatin modified DNA [CP9/19]
Cancers detailed: Broadly Applicable;Chemotherapy
Research fields: Cancer;Genetics
Clone: CP9/19
Tool sub type: Primary antibody
Class: Monoclonal
Conjugation: Unconjugated
Host: Rat
Application: ELISA ; FACS ; IHC ; IP ; DB
Description: Antibody CP9/19 recognises only the intra-strand cross-links formed by cisplatin between adjacent purines.
Immunogen: Cisplatin modified native DNA
Isotype: IgG2a
Myeloma used: Y3.AG.1.2.3
Recommended controls: RNA/DNA

Target Details

Target: Cisplatin modified native DNA
Tissue cell line specificity: RNA/DNA
Target background: This antibody enables the quantification of cisplatin-induced adducts on DNA. This antibody has also been recently used for isolation of DNA fragments carrying adducts to enhance the sensitivity of subsequent PCR-based analyses and is central to ongoing studies of variation in the nature of cisplatin adducts formed in different cell lines.

Applications

Application: ELISA ; FACS ; IHC ; IP ; DB

Handling

Format: Liquid
Concentration: 1 mg/ml
Unit size: 100 ug
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice

Related Tools

Related tools: Anti-Cisplatin modified DNA, Recombinant [CP9/19]

References

Powell et al. 2015. Sci Rep. 5:7975. PMID: 25609656.
3D-DIP-Chip: a microarray-based method to measure genomic DNA damage.
Kothandapani et al. 2012. Exp Cell Res. 318(16):1973-86. PMID: 22721696.
Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.
Kothandapani et al. 2011. J Biol Chem. 286(16):14564-74. PMID: 21357694.
Novel role of base excision repair in mediating cisplatin cytotoxicity.
Meczes et al. 2005. Biochem Pharmacol. 70(12):1...

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