Anti-CHIKV [3E7b] mAb

Monoclonal antibody capable of neutralising CHIKV replication and can detect infection of cells.

Contributors

Institute
A*STAR Accelerate Technologies Pte Ltd
Cat. #: 153198
Unit size: 100 ug
Research Fields: Microbiology
Application: ELISA ; IHC ; Fn ; WB
Target: N218 epitope on E2 protein of CHIKV
Reactivity: Virus
Clone: 3E7b
Host: Mouse
Class: Monoclonal
Primary citation: Lam et al. 2015. MAbs. 7(6):1178-1194. PMID: 26305993.
Alternate name: Chikungunya virus; Chikungunya virus antibody
Product description: Anti-CHIKV [3E7b] binds strongly to the native CHIKV surface. This monoclonal antibody is also capable of detecting infection of cells. Chikungunya virus (CHIKV) is an alphavirus known to cause severe polyarthritis and polyarthralgia. CHIKV is transmitted to humans by mosquito vectors, primarily Aedes aegypti and Aedes albopictus. 3E7b potently neutralises CHIKV replication. Additionally, Anti-CHIKV [3E7b] protected mice from CHIKV disease when administered prior to CHIKV infection.
Conjugation: Unconjugated
Isotype: IgM
Immunogen: Live chikungunya virus
Immunogen Uniprot ID: Q8JUX5
Myeloma used: Sp2/0-Ag14
Target background: Chikungunya virus (CHIKV) is an alphavirus which causes febrile illness with severe polyarthralgia, known to be transmitted to humans by mosquito vectors, primarily Aedes aegypti and A. albopictus. Symptoms include high fever, asthenia, chills, headache, diarrhoea, vomiting and rash. Since the re-emergence of CHIKV in La Reunion, epidemic outbreaks of CHIKV infection have been reported globally and CHIKV is now considered endemic in 34 countries across Europe, Australia, Asia and Africa.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Lam et al. 2015. MAbs. 7(6):1178-1194. PMID: 26305993.

Images

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Anti-CHIKV IgM (3E7b) and (8A2c) are used to stained chikungunya virus-infected cell. There is no staining observed in the mock infected cells. DAPI was used to stain the nucleus of the cells.

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