CD79a is found in B cell lymphomas, in B cell lines, the majority of acute leukemias of precursor B cell type and in some myelomas.
| Inventor | Institute |
|---|---|
| Jacqueline Cordell | University of Oxford |
| Cat. #: | 151468 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Cell signaling and signal transduction;Immunology;Stem cell biology |
| Application: | IHC ; IP ; WB |
| Target: | CD79a |
| Reactivity: | Bovine ; Chicken ; Horse ; Human ; Guinea Pig ; Mouse ; Opossum ; Pig ; Primate ; Rat ; Rabbit |
| Clone: | HM47 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | B-cell antigen receptor complex-associated protein alpha chain; Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein |
|---|---|
| Product description: | The B cell Antigen receptor constitutes a disulphide linked heterodimer, consisting of CD79a / mb1 and CD79b / B29 polypeptides, non covalently associated with membrane bound immunoglobulins on B cells. CD79a first appears at pre B cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in B cell lymphomas, in B cell lines, the majority of acute leukemias of precursor B cell type and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). Induction of tyrosine kinase activity after antigen binding causes phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signaling. CD79a is widely used as an adjunct to CD20 for detecting normal and neoplastic B cells in tissues sections. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Synthetic peptide of 14 amino acids representing amino acids 202-216 of the human mb-1 cDNA sequence |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | The B cell Antigen receptor constitutes a disulphide linked heterodimer, consisting of CD79a / mb1 and CD79b / B29 polypeptides, non covalently associated with membrane bound immunoglobulins on B cells. CD79a first appears at pre B cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in B cell lymphomas, in B cell lines, the majority of acute leukemias of precursor B cell type and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). Induction of tyrosine kinase activity after antigen binding causes phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signaling. CD79a is widely used as an adjunct to CD20 for detecting normal and neoplastic B cells in tissues sections. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Lankester et al. 1994. J Immunol. 152(5):2157-62. PMID: 8133032. Evidence for a direct physical interaction of membrane IgM, IgD, and IgG with the B29 gene product. Brouns et al. 1993. Eur J Immunol. 23(5):1088-97. PMID: 8477803. The structure of the mu/pseudo light chain complex on human pre-B cells is consistent with a function in signal transduction. Mason et al. 1991. J Immunol. 147(11):2474-82. PMID: 1747162. The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells. van Noesel et al. 1991. J Immunol. 146(11):3881-8. PMID: 2033258. The membrane IgM-associated heterodimer on human B cells is a newly defined B cell antigen that contains the protein product of the mb-1 gene. |
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