Cat. #151355
Anti-CD21L [R4/23] mAb
Cat. #: 151355
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 1-2 weeks
Target: Complement component (3d/Epstein Barr virus) receptor 2; long form (CR2, CD21L)
Class: Monoclonal
Application: IHC ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Jacqueline Cordell
Institute: University of Oxford
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-CD21L [R4/23] mAb
- Alternate name: Complement Component (3d/Epstein Barr Virus) Receptor 2; Epstein-Barr Virus Receptor 2; Complement C3d Receptor 3; EBV Receptor 3; C3DR 3; CD21 Antigen; CVID7; SLEB9; CD21; Cr2
- Research fields: Cell biology;Immunology
- Clone: R4/23
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: IHC ; WB
- Description: R4/23 recognises the long form of CR2 and can be used to identify dendritic reticulum cells (or their remnants) in lymphoid tissues.
- Immunogen: Cell lysate from a chronic lymphocytic leukemia patient.
- Isotype: IgM
- Myeloma used: P3/NS1/1-Ag4.1
Target Details
- Target: Complement component (3d/Epstein Barr virus) receptor 2; long form (CR2, CD21L)
- Target background: CR2 is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. CR2 functions as a receptor for C3d, C3dg and iC3b Complement components and for EBV and for IFN alpha. Follicular dendritic cells (contained in B cell follicles) selectively express the Long isoform of CR2 (CD21L) that contains an additional exon (10a) compared to CR2 (CD21).
Applications
- Application: IHC ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Nakamura et al. 1999. Am J Surg Pathol. 23(4):363-76. PMID: 10199466.
- Hodgkin's disease expressing follicular dendritic cell marker CD21 without any other B-cell marker: a clinicopathologic study of nine cases.
- Heinen et al. 1984. Eur J Immunol. 14(3):267-73. PMID: 6368249.
- Isolation of follicular dendritic cells from human tonsils and adenoids. II. Immunocytochemical characterization.
- Naiem et al. 1983. J Clin Pathol. 36(2):167-75. PMID: 6338047.
- Production of a monoclonal antibody reactive with human dendritic reticulum cells and its use in the immunohistological analysis of lymphoid tissue.
- Stein et al. 1982. Int J Cancer. 30(4):445-59. PMID: 6754630.
- Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population.
