Anti-Big (high-molecular-weight) tau

Tau is a neuronal microtubule associated protein (MAP) which has multiple isoforms that are differentially expressed during development. Big tau is a high molecular weight isoform that contains an additional large exon (4a) and is expressed primarily by neurons in the peripheral nervous system. Big tau expression has also been shown in the developing spinal […]

Contributors

Inventor Institute
Itzhak Fischer Drexel University
Cat. #: 154129
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Developmental biology;Neurobiology
Application: IHC ; WB
Target: Big tau (high-molecular-weight)
Reactivity: Rat
Host: Rabbit
Class: Polyclonal
Product description: Tau is a neuronal microtubule associated protein (MAP) which has multiple isoforms that are differentially expressed during development. Big tau is a high molecular weight isoform that contains an additional large exon (4a) and is expressed primarily by neurons in the peripheral nervous system. Big tau expression has also been shown in the developing spinal cord and in the adult central nervous system. Big tau may be important in stabilizing microtubules in axons that are subjected to great s…
Conjugation: Unconjugated
Immunogen: Recombinant protein of the complete 4a exon of tau, specific to the Big tau isoform, was used to produce antibody
Target background: Tau is a neuronal microtubule associated protein (MAP) which has multiple isoforms that are differentially expressed during development. Big tau is a high molecular weight isoform that contains an additional large exon (4a) and is expressed primarily by neurons in the peripheral nervous system. Big tau expression has also been shown in the developing spinal cord and in the adult central nervous system. Big tau may be important in stabilizing microtubules in axons that are subjected to great s…
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Boyne et al. 1995. J Comp Neurol. 358(2):279-93. PMID: 7560287.

Distribution of Big tau in the central nervous system of the adult and developing rat.

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