Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 1 is differentiation specific keratin that is one of the predominant keratins in […]
| Inventor | Institute |
|---|---|
| Irene Leigh | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 152683 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction |
| Application: | IHC ; IHC |
| Target: | Keratin 1, Cytokeratin 1 |
| Reactivity: | Human |
| Clone: | LL017 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 1 is differentiation specific keratin that is one of the predominant keratins in suprabasal keratinocytes in stratified epthelia. Mutations in keratin 1 causes epidermolytic hyperkeratosis. LL017 does not react with any tumour tissue regardless of histological classification. |
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| Conjugation: | Unconjugated |
| Isotype: | IgM |
| Immunogen: | Synthetic peptide – VSTTYSGVTR |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 1 is differentiation specific keratin that is one of the predominant keratins in suprabasal keratinocytes in stratified epthelia. Mutations in keratin 1 causes epidermolytic hyperkeratosis. LL017 does not react with any tumour tissue regardless of histological classification. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
de Berker et al. 1995. Exp Dermatol. 4(6):350-6. PMID: 8608342. Keratin expression in discoid lupus erythematosus. Leigh et al. 1993. Br J Dermatol. 129(2):110-9. PMID: 7544603. Monospecific monoclonal antibodies to keratin 1 carboxy terminal (synthetic peptide) and to keratin 10 as markers of epidermal differentiation. Markey et al. 1992. Br J Dermatol. 126(2):154-60. PMID: 1371396. Keratin expression in basal cell carcinomas. Ishida-Yamamoto et al. 1991. J Invest Dermatol. 97(6):959-68. PMID: 1721080. Epidermolysis bullosa simplex (Dowling-Meara type) is a genetic disease characterized by an abnormal keratin-filament network involving keratins K5 and K14. |
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