#153538

pSIEW-RUNX1-EVI1 Vector

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Cat. #153538

pSIEW-RUNX1-EVI1 Vector

Cat. #: 153538

Sub-type: pSIEW

Availability: 3-5 days

Target: RUNX1-EVI1 (chimeric gene)

Bacterial Resistance: Ampicillin

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Constanze Bonifer

Institute: University of Birmingham

Tool Details
Handling
Target Details
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: pSIEW-RUNX1-EVI1 Vector
  • Alternate name: Runt Related Transcription Factor 1, RUXN1, AML1, AML1-EVI-1, AMLCR1, CBF2alpha, CBFA2, EVI-1, PEBP2aB, PEBP2alpha, acute myeloid leukemia 1 protein, core-binding factor subunit alpha-2
  • Research fields: Cancer;Cell signaling and signal transduction;Genetics
  • Tool sub type: pSIEW
  • Backbone size without insert: 14400
  • Bacterial resistance: Ampicillin
  • Description: Runt-related transcription factor 1, a protein that in humans is encoded by the RUNX1 gene, that regulates the differentiation of hematopoietic stem cells into mature blood cells and plays a major role in the development of the neurons that transmit pain. It belongs to the RUNX family of genes also known as core binding factor-a, and RUNX proteins form heterodimeric complexes with these confering increased DNA binding and stability. Chromosomal translocations involving RUNX1 are associated with several types of leukemia including M2 Acute myeloid leukaemia and DNA mutations are implicated in cases of breast cancer.

Handling

  • Storage conditions: -20° C
  • Shipping conditions: Dry Ice

Target Details

  • Target: RUNX1-EVI1 (chimeric gene)

References

  • Maki et al. 2008. Cancer Sci. 99(10):1878-83. PMID: 19016745.
  • Role of the RUNX1-EVI1 fusion gene in leukemogenesis.