Cat. #153578
PI4K beta Inhibitor Small Molecule (Tool Compound)
Cat. #: 153578
Sub-type: Inhibitor
Availability: Please enquire for quantities and pricing
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Martin Swarbrick
Institute: Cancer Research Technology AstraZeneca Metabolism Alliance Team
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: PI4K beta Inhibitor Small Molecule (Tool Compound)
- Research fields: Cancer
- Molecular formula: C23H25N5O4S2
- Tool sub type: Inhibitor
- Description: Potent and selective small molecule inhibitor of PI4K?, an isoform mainly associated with the Golgi complex where it functions in the generation of Golgi-derived carriers. In addition to the Golgi apparatus, PI4K? has also been visualised on lysosomes where it functions to maintain lysosomal membrane integrity. In a cellular environment, inhibition of PI4K? does not lead to a reduction in phosphatidylionositol-4-phosphate and phosphatidylionositol-4,5-biphosphate concentration
- Purpose: Inhibitor
- Selectivity: 5.1 (PI4KÎą); 4.7 (PI3KÎą); <4.0 (PIP5KÉŁ); no activity against any kinase in the Millipore kinase panel (259 kinases; tested at 1ÂľM)
- Molecular weight: 499.13
- Solubility: 5 ľM
- Additional notes: Compound 3 (PMID: 24366037). AstraZeneca Alliance.
Handling
- Purity: 499.13 g/mol
- Shipping conditions: Dry Ice
Target Details
- Ic50: 7.8 (PI4Kβ)
References
- Raubo et al. 2015. Bioorg Med Chem Lett. 25(16):3189-93. PMID: 26087940. Waring et al. 2014. Chem Commun (Camb). 50(40):5388-90. PMID: 24366037.
