Cat. #153578

PI4K beta Inhibitor Small Molecule (Tool Compound)

Cat. #: 153578

Sub-type: Inhibitor

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Contributor

Inventor: Martin Swarbrick

Institute: Cancer Research Technology AstraZeneca Metabolism Alliance Team

Tool Details

Handling

Target Details

References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

Tool name: PI4K beta Inhibitor Small Molecule (Tool Compound)
Research fields: Cancer
Molecular formula: C23H25N5O4S2
Tool sub type: Inhibitor
Description: Potent and selective small molecule inhibitor of PI4K?, an isoform mainly associated with the Golgi complex where it functions in the generation of Golgi-derived carriers. In addition to the Golgi apparatus, PI4K? has also been visualised on lysosomes where it functions to maintain lysosomal membrane integrity. In a cellular environment, inhibition of PI4K? does not lead to a reduction in phosphatidylionositol-4-phosphate and phosphatidylionositol-4,5-biphosphate concentration
Purpose: Inhibitor
Selectivity: 5.1 (PI4KÎą); 4.7 (PI3KÎą); <4.0 (PIP5KÉŁ); no activity against any kinase in the Millipore kinase panel (259 kinases; tested at 1ÂľM)
Molecular weight: 499.13
Solubility: 5 ľM
Additional notes: Compound 3 (PMID: 24366037). AstraZeneca Alliance.

Handling

Purity: 499.13 g/mol
Shipping conditions: Dry Ice

Target Details

Ic50: 7.8 (PI4KÎ˛)

References

Raubo et al. 2015. Bioorg Med Chem Lett. 25(16):3189-93. PMID: 26087940. Waring et al. 2014. Chem Commun (Camb). 50(40):5388-90. PMID: 24366037.