Cat. #160588
Penta-PT conjugate small molecule (tool compound)
Cat. #: 160588
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This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Czeslaw Lugowski ; Tomasz Niedziela ; Sabina Koj
Institute: Polish Center for Technology Development/Polski OĹrodek Rozwoju Technologii (PORT)
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: Penta-PT conjugate small molecule (tool compound)
- Research fields: Drug development;Immunology
- Description: Adapted from WO2014/195881 Bordetella pertussis causes whooping cough, a highly contagious disease involving the respiratory tract, which is especially serious for infants and young children. Despite widespread immunization, in recent years the number of pertussis incidences has increased. The limited efficacy of currently used pertussis vaccines results from the fact that their components do not induce a complete immune response. Unlike tetanus and diphtheria diseases where all symptoms are ...
- Selectivity: This pentasaccharide-PT glycoconjugate is not capable of binding to fetuin in ELISA test.
- Additional notes: Adapted from WO2014/195881 Glycoconjugate of the distal pentasaccharide obtained by deamination of LOS (from Bordetella pertussis) conjugated to a pertussis toxin. The pentasaccharide part of the conjugate is a fragment isolated from the LOS of B. pertussis 186 and it comprises a distal trisaccharide, a heptose and an anhydromannose. It has been shown that pentasaccharide-TTd conjugate induced antibodies which were able to bind to B. pertussis in immunofluorescence assays (FACS). Moreover, us...
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References
- WO2014195881 - BORDETELLA PERTUSSIS LOS-DERIVED OLIGOSACCHARIDE WITH PERTUSSIS TOXIN GLYCOCONJUGATE AND ITS APPLICATION IN THE PROPHYLAXIS AND TREATMENT OF INFECTIONS CAUSED BY BORDETELLA PERTUSSIS
